Multicenter Perioperative Opioid Pharmacogenetic Study

Not Recruiting

Trial ID: NCT01495611


The purpose of this research study is to identify factors and genes (the DNA material that determines the makeup of the human body) that may be associated with how children respond to pain medication. Specifically, the investigators want to study factors that may be associated with pain sensitivity, morphine requirement after surgery and side-effects from morphine and other pain medications. The investigators expect that the information obtained in this research study will help us to develop more effective, safe, and tailored treatment options in the future.

Official Title

Predicting Perioperative Opioid Adverse Effects and Personalizing Analgesia in Children: A Multicenter Pharmacogenetic Study

Stanford Investigator(s)


Inclusion Criteria:

   - children 6-17 years of age

   - ASA physical status 1 and 2

   - scheduled for tonsillectomy (T) and tonsillectomy and adenoidectomy (T and A)

   - Children with obstructive sleep apnea will also be included.

Exclusion Criteria:

   - children with developmental delay

   - liver and renal diseases,

   - preoperative pain requiring analgesics (e.g. chronic tonsillitis).

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
R J Ramamurthi