Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects


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Trial ID: NCT02090140


The purpose of this study is to compare two biologic methods for the treatment of articular cartilage defects in the knee. The first method, microfracture, is the standard of care and is routinely used to recruit cells from the subchondral bone marrow to the site of cartilage loss. The second method is the application of adipose-derived stem cells (ADSCs) to the defect site. In theory, ADSCs on a collagen scaffold should enable the delivery of more specific progenitor cells to the site of injury, resulting in better regeneration and integration of articular cartilage at the site of a defect as compared to the microfracture method.

Official Title

Randomized Controlled Trial of Microfracture Versus Adipose Derived Stem Cells for the Treatment of Isolated Articular Cartilage Defects

Stanford Investigator(s)

Seth Lawrence Sherman, MD
Seth Lawrence Sherman, MD

Associate Professor of Orthopaedic Surgery


Inclusion Criteria:

   - Must be between ages 18 and 50 years.

   - Must have a discrete, contained chondral defect less than 400mm^2 located on the
   medial or lateral femoral condyle

   - Must have overall neutral lower limb mechanical alignment (<5 degrees varus or

Exclusion Criteria:

   - Ages younger than 18 years and older than 50 years.

   - If they have undergone previous chondral procedures

   - If they have pre-existing osteoarthritis (Kellegren-Lawrence Grade ≥2)

   - If they have a BMI >30.


procedure: ADSC Application

procedure: Microfracture


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Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Jan Yabut