Management of Palmar Hyperhidrosis With Hydrogel-based Iontophoresis

Inclusion Criteria:

* 13 years of age or older
* \>6 months self-reported history of primary palmar hyperhidrosis
* Initial gravimetry test: \>20mg/min on each palm
* No topical treatments for hyperhidrosis (antiperspirants) on the palms for 2 weeks prior to the start of the study
* No systemic treatments for hyperhidrosis (anticholinergics) for 4 weeks prior to the start of the study
* No tap water iontophoresis treatment for 6 weeks
* No Botox injections on the palms for 6 months (if single treatment session) or 10 months (if \>1 previous sessions) prior to the start of the study
* No history of cardiothoracic sympathectomy for hyperhidrosis
* Able to attend 3 office visits (Stanford Medical Outpatient Center located at 450 Broadway St, Redwood City, CA 94063; Lucile Packard Children's Hospital at 730 Welch Road, 1st Floor, Palo Alto, CA 94304) and one virtual visit in an 8 week time frame
* Capable of performing sweat level testing and hydrogel-based iontophoresis treatment at home, after training
* Hydrogel electrode pad fits on the hand (typically tip of middle finger to lower end of palm length of 6.5in (16.5cm) or greater)

Exclusion Criteria:

* Patients with implanted electronic medical devices e.g. pacemaker, implantable cardioverter/defibrillator)
* Patients with metal implants in the extremity that will be treated
* Patients with larger skin defects (on the palm or arm of the extremity that will be treated) that cannot be covered by petroleum jelly
* Pregnant or nursing women, or looking to become pregnant
* Patients on medications that interfere with neuroglandular transmission
* Patients with active infection locally or systemically
* Patients with history of contact dermatitis to acrylates
* Patients with history of contact or systemic allergy to iodine
* Patients with a history of ischemic heart disease, cardiac arrhythmias, epilepsy or thyroid disease