Management of the PDA Trial


Trial ID: NCT03456336


Estimate the risks and benefits of active treatment versus expectant management of a symptomatic patent ductus arteriosus (sPDA) in premature infants.

Official Title

Management of the Patent Ductus Arteriosus in Premature Infants Trial (PDA Trial)

Stanford Investigator(s)


Inclusion Criteria:

   - Postnatal age 48 hours -21 days

   - Infant 22 0/7 to 28 6/7 weeks gestation at birth

   - sPDA, as defined as:

      1. Mild, Moderate, or Severe Clinical Criteria with Small or Moderate size PDA on

      2. Mild or Moderate Clinical Criteria with Large PDA on echocardiogram

Exclusion Criteria:

   - Cardiopulmonary compromise

   - Known congenital heart disease (besides atrial septal defect or ventricular septal

   - Known pulmonary malformation (e.g. congenital lobar emphysema, congenital pulmonary
   adenomatous malformation)

   - Any condition which, in the opinion of the investigator, would preclude enrollment


other: Active Treatment

other: Expectant Management


Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Krisa P. Van Meurs, MD