Magnesium for Peroral Endoscopic Myotomy

Not Recruiting

Trial ID: NCT04638881


Postoperative pain after peroral endoscopic myotomy occurs due to involuntary esophageal smooth muscle spasms. Magnesium has antispasmodic properties as a smooth muscle relaxant. This study hypothesizes that among patients having peroral endoscopic myotomy, magnesium will decrease postoperative esophgeal pain as measured by the esophageal symptoms questionnaire, while decreasing perioperative opioid requirements.

Official Title

A Prospective, Randomized, Double-blind, Placebo-controlled Trial of the Effects of Magnesium Sulfate on Postoperative Esophageal Spasm-associated Pain Following Peroral Endoscopic Myotomy

Stanford Investigator(s)

Joo Ha Hwang, MD, PhD
Joo Ha Hwang, MD, PhD

Professor of Medicine (Gastroenterology and Hepatology) and, by courtesy, of Surgery


Inclusion Criteria:

- Planned peroral endoscopic myotomy procedure

Exclusion Criteria:

   - cannot give consent

   - patients who are clinically unstable and/or require urgent/emergent intervention

   - previous esophageal myotomy

   - preexisting hypermagnesemia

   - end-stage renal disease

   - neuromuscular disease, including but not limited to Guillain-Barre syndrome,
   myasthenia gravis, congenital myopathy, and muscular dystrophy

   - preexisting heart failure

   - severe ventricular systolic dysfunction (left or right ventricle)


drug: Magnesium sulfate

drug: Normal Saline

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Richard K Kim, MD