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Magnesium for Peroral Endoscopic Myotomy
Not Recruiting
Trial ID: NCT04638881
Purpose
Postoperative pain after peroral endoscopic myotomy occurs due to involuntary esophageal
smooth muscle spasms. Magnesium has antispasmodic properties as a smooth muscle relaxant.
This study hypothesizes that among patients having peroral endoscopic myotomy, magnesium will
decrease postoperative esophgeal pain as measured by the esophageal symptoms questionnaire,
while decreasing perioperative opioid requirements.
Official Title
A Prospective, Randomized, Double-blind, Placebo-controlled Trial of the Effects of Magnesium Sulfate on Postoperative Esophageal Spasm-associated Pain Following Peroral Endoscopic Myotomy
Stanford Investigator(s)
Joo Ha Hwang, MD, PhD
Professor of Medicine (Gastroenterology and Hepatology) and, by courtesy, of Surgery
Eligibility
Inclusion Criteria:
- Planned peroral endoscopic myotomy procedure
Exclusion Criteria:
- cannot give consent
- patients who are clinically unstable and/or require urgent/emergent intervention
- previous esophageal myotomy
- preexisting hypermagnesemia
- end-stage renal disease
- neuromuscular disease, including but not limited to Guillain-Barre syndrome,
myasthenia gravis, congenital myopathy, and muscular dystrophy
- preexisting heart failure
- severe ventricular systolic dysfunction (left or right ventricle)
Intervention(s):
drug: Magnesium sulfate
drug: Normal Saline
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Richard K Kim, MD
347-586-9661