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Nerve Transfer After Spinal Cord Injury- Multi-center
Recruiting
I'm InterestedTrial ID: NCT04023591
Purpose
Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment
options that provide meaningful improvements in patient quality of like and long-term
functional independence will provide a significant public health impact. Specific aim:
Measure the efficacy of nerve transfer surgery in the treatment of patients with complete
spinal cord injuries with no hand function. Optimize the efficiency of nerve transfer surgery
by evaluating patient outcomes in relation to patient selection and quality of life and
functional independence.
Official Title
Nerve Transfers to Improve Upper Extremity Function and Quality of Life in Tetraplegic Patients
Stanford Investigator(s)
Thomas J. Wilson
Clinical Associate Professor, Neurosurgery
Eligibility
Inclusion Criteria
1. Age 18-65, inclusive
2. At least 3 months of non-operative rehab therapy
3. Mentally and physically willing and able to comply with evaluations
4. Less than 36 months post-injury
5. Stable ASIA scores with no evidence of functional improvement in motor or sensory
examination for at least 3 months
6. ASIA A or B determined by the International Standards for Neurological Classification
of Spinal Cord Injury (ISNCSCI)
7. EMG/NCS verifies intact innervation (normal CMAPs) to the paralyzed target muscles
below the level of injury
8. Functional electrical stimulation (FES) will be performed. Subject must have
clinically normal MRC grade 5/5 donor (axonal) function
9. Injury Level C4-C8
Exclusion Criteria
1. Active infection at the operative site or systemic infection
2. Any return or ongoing clinical recovery of distal motor function
3. Mentally or physically compromised that will prevent them from complying with
evaluations.
4. Immunologically suppressed
5. Currently undergoing long-term steroid therapy
6. Active malignancy
7. Pregnant
8. Significant joint contractures and/or limitations in passive range of motion in the
arm or hand, per treating surgeon's discretion
9. Lack of appropriate social support and/or infrastructure to commit to scheduled
follow-up visits.
10. Patients who are planning on undergoing a tendon transfer during the study period or
who have had a tendon transfer in the past.
Intervention(s):
procedure: Surgery/Occupational Therapy
Recruiting
I'm InterestedContact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Thomas J Wilson, MD
650-723-0320