NA-AION Risk Factors: New Perspectives

Recruiting

Trial ID: NCT05305079

Purpose

The purpose of the study is to use new diagnostic methods (OCT and OCT-A) to shed light on risk factors for the development of NA-AION. The risk factors we are focusing on are comorbidities along with anatomical and vascular characteristics of the optic nerve.

Official Title

Non-Arteritic Anterior Ischemic Optic Neuropathy Risk Factors: New Perspectives

Stanford Investigator(s)

Y. Joyce Liao, MD, PhD
Y. Joyce Liao, MD, PhD

Stanford Medicine Professor of Ophthalmology and Professor of Neurology

Heather E. Moss, MD, PhD
Heather E. Moss, MD, PhD

Professor of Ophthalmology and of Neurology

Shannon Beres, MD
Shannon Beres, MD

Clinical Associate Professor, Neurology & Neurological Sciences Clinical Associate Professor (By courtesy), Ophthalmology

Eligibility


Inclusion Criteria:

   1. Diagnosis of first episode of NA-AION in study eye with symptom onset within 14 days
   prior

   2. Subject age: Age >10

   3. NA-AION diagnosis requires:

      - disc edema seen and documented by site PI

      - visual field defect in the study eye consistent with NA-AION and mean deviation
      worse than 3.0 dB using the study visual field examination protocol

      - relative afferent pupillary defect (unless the fellow eye had previous NA-AION or
      other optic nerve or retinal disease that is not exclusionary)

Exclusion Criteria:

   1. Previous episode of NA-AION in the study eye only

   2. Intraocular pressure of >21 mm Hg in the study eye

   3. Clinical or pathological evidence of giant cell arteritis

   4. Diseases that may affect the optic nerve: glaucoma, multiple sclerosis, Alzheimer
   disease, and Parkinson disease. Evidence of optic disc drusen and optic nerve
   hypoplasia are not exclusion criteria given they are important parts of the study. We
   will not exclude significant retinal diseases, since they may be related to underlying
   etiologies giving rise to ODD, such as macular degeneration, retinal dystrophies, but
   eyes with significant retinal diseases will be analyzed separately.

Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305