Phase I Dose Escalation of Stereotactic Radiosurgical Boost for Locally Advanced Esophageal Cancer

Inclusion Criteria:- Confirmed diagnosis of adenocarcinoma or squamous cell carcinoma of
the esophagus by pathologist.

   - Endoscopic ultrasound or CT evidence of tumor penetration through the esophageal wall
   or involvement of regional lymph nodes, without evidence of distant metastasis

   - No prior chest radiation therapy

   - No prior chemotherapy for esophageal cancer

   - Age greater than 18 years

   - No infections requiring antibiotic treatment

   - Able to care for self

   - Patients must have acceptable liver, kidney and bone marrow function.

   - The effects of the chemotherapy drugs on the developing human fetus are unknown. Women
   of child-bearing potential and men must agree to use adequate contraception. Exclusion
   Criteria:- Patients receiving any other investigational agents

   - Evidence of distant metastases

   - Uncontrolled medical illness

   - Any malignancy other than non-melanoma skin cancer or carcinoma in situ of the cervix.

   - Pregnant and breastfeeding women are excluded.

   - HIV-positive patients