Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications

Not Recruiting

Trial ID: NCT00809146


The goal of this non-inferiority trial is to determine which type of routine care is the best for paramedics to stop someone from seizing.

Official Title

A Double-blind Randomized Clinical Trial of the Efficacy of IM Midazolam Versus IV Lorazepam in the Pre-hospital Treatment of Status Epilepticus by Paramedics

Stanford Investigator(s)

James Quinn
James Quinn

Professor of Emergency Medicine, Emeritus


Inclusion Criteria:

   - Paramedics or reliable witnesses verify 5 minutes of either continuous seizure
   activity or of repeated convulsive seizure activity where the patient does not regain
   consciousness (operationally defined as meaningful speech or obeying commands) between

   - Patient is still seizing at the time of paramedic treatment with study medications.

   - Estimated weight equal to or greater than 13 kg.

   - Subject to be transported to a RAMPART participating hospital.

Exclusion Criteria:

   - Major trauma as the precipitant of the seizure

   - Hypoglycemia (as defined by local EMS protocol or a glucose < 60 mg/dL)

   - Known allergy to midazolam or lorazepam

   - Cardiac arrest or heart rate (HR) <40 beats per minute

   - Sensitivity to benzodiazepines

   - Medical alert tag marked with "RAMPART declined"

   - Prior treatment of this seizure with diazepam autoinjector as part of another study

   - Known pregnancy

   - Prisoners


drug: Intramuscular route of active treatment

drug: Intravenous route of active treatment

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Rosen Mann