Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial

Not Recruiting

Trial ID: NCT00946088


Preterm delivery is the most common cause of infant morbidity and mortality in the United States. Some women have episodes of preterm labor during their pregnancy which can be temporarily stopped. These women, however, are at high risk for delivering before term. At this time, we do not have sufficient evidence to use any medication to help prevent these women from delivering early. Recently, preliminary studies have shown that progesterone may help prevent some women at high risk for preterm delivery from delivering early. Our study will investigate whether progesterone can help this specific group of women, women with arrested preterm labor, deliver healthy infants at term.

Official Title

Progesterone for Maintenance Tocolysis: A Randomized Placebo Controlled Trial

Stanford Investigator(s)

Yasser El-Sayed, Professor
Yasser El-Sayed, Professor

Charles B. and Ann L. Johnson Professor in the School of Medicine and Professor, by courtesy, of Pediatrics (Neonatology) and of Surgery

Maurice L. Druzin
Maurice L. Druzin

Professor of Obstetrics and Gynecology (Maternal Fetal Medicine) and, by courtesy, of Pediatrics


Inclusion Criteria:1. Pregnant women with arrested preterm labor between 24+0 to 33+6 weeks

2. Intact membranes 3. Singleton pregnancy 4. Greater than or equal to 18 years of age 5.
Cervical dilation less than or equal to 4cm Exclusion Criteria:1. Any contraindication to
on-going pregnancy 2. Placental abruption 3. Placenta previa 4. Lethal fetal anomalies 5.
Premature rupture of membranes 6. Multiple gestation 7. Less than 18 years old 8. Known
allergy to any component of the study medication or placebo 9. Severe maternal medical


drug: Polyethylene glycol&hydrogenated vegetable oil.

drug: Progesterone

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Elizabeth S Langen, MD