Pazopanib in Imatinib Refractory or Intolerant Gastrointestinal Stromal Tumors (GIST)

Not Recruiting

Trial ID: NCT01391611


This study is being done to gather information about the safety (any harmful effects) and effectiveness (usefulness) of Pazopanib in the treatment of Gastrointestinal Stroma Tumors (GIST) that cannot be treated by surgery or has spread to other organs. The Food and Drug Administration (FDA) have approved Pazopanib for the treatment of advanced kidney cancer but it is not approved for the treatment of GIST. The investigators hope to learn about the safety and usefulness (effectiveness) of Pazopanib for patients with GIST. Primary Objective: Non-progression rate based on RECIST criteria (CR+PR+SD) Secondary Objectives: - Response per Choi criteria - 6 month progression-free survival - Safety and tolerability

Official Title

A Phase II Study of Pazopanib in Patients With Imatinib Refractory or Intolerant Gastrointestinal Stromal Tumors (GIST)

Stanford Investigator(s)

Kristen N Ganjoo
Kristen N Ganjoo

Professor of Medicine (Oncology)


Inclusion Criteria:

   - Metastatic or unresectable gastrointestinal stromal tumor (GIST)

   - Failure or intolerance to Imatinib and sunitinib

   - Subjects must provide written informed consent prior to performance of study-specific
   procedures or assessments, and must be willing to comply with treatment and follow up.

   - Procedures conducted as part of the subject's routine clinical management (e.g., blood
   count, imaging study) and obtained prior to signing of informed consent may be
   utilized for screening or baseline purposes provided these procedures are conducted as
   specified in the protocol.

   - Age >= 18 years

   - Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

   - Measurable disease criteria by RECIST criteria

   - Adequate organ system function as defined in protocol.

   - A female is eligible to enter and participate in this study if she is of
   non-childbearing potential (i.e., physiologically incapable of becoming pregnant).
   This includes any female who has had:

   - A hysterectomy

   - A bilateral oophorectomy (ovariectomy)

   - A bilateral tubal ligation

   - Menopause

   - Childbearing potential females must have a negative serum pregnancy test within 2
   weeks prior to the first dose of study treatment, preferably as close to the first
   dose as possible, and agree to use adequate contraception. Adequate acceptable
   contraceptive methods, when used consistently and in accordance with both the product
   label and the instructions of the physician, are as follow:

   - An intrauterine device with a documented failure rate of less than 1% per year.

   - Vasectomized partner who is sterile prior to the female subject?s entry and is the
   sole sexual partner for that female.

   - Complete abstinence from sexual intercourse for 14 days before exposure to
   investigational product, through the dosing period, and for at least 21 days after the
   last dose of investigational product.

Double-barrier contraception (condom with spermicidal jelly, foam suppository, or film;
diaphragm with spermicide; or male condom and diaphragm with spermicide edify eligible

Exclusion Criteria:

   - History of other malignancies within 5 years prior to Day 1 except for tumors with a
   negligible risk for metastasis or death, such as adequately controlled basal cell
   carcinoma, squamous-cell carcinoma of the skin, carcinoma in situ of the cervix,
   early-stage bladder cancer, or low-grade endometrial cancer

   - Clinically significant gastrointestinal abnormalities that may affect absorption of
   the investigational product

   - Presence of uncontrolled infection

   - Prolongation of corrected QT interval (QTc) > 480 milliseconds. On antiarrhythmics or
   medications known to prolong QT interval

   - History of any one or more of the following cardiovascular conditions within the past
   6 months:

   - Cardiac angioplasty or stenting

   - Myocardial infarction

   - Unstable angina

   - Coronary artery by-pass graft surgery

   - Symptomatic peripheral vascular disease

   - Class III or IV congestive heart failure, as defined by the New York Heart Association

   - Poorly controlled hypertension [defined as systolic blood pressure (SBP) of >=140 mmHg
   or diastolic blood pressure (DBP) of >= 90mmHg].

   - History of cerebrovascular accident, hemoptysis, cerebral hemorrhage, clinically
   significant GI bleed, pulmonary embolism or untreated deep venous thrombosis (DVT)
   within the past 6 months

   - Prior major surgery or trauma within 28 days prior to first dose of study drug and/or
   presence of any non-healing wound, fracture

   - Evidence of active bleeding or bleeding diathesis.

   - Any serious and/or unstable pre-existing medical, psychiatric, or other condition that
   could interfere with subject's safety, provision of informed consent, or compliance to

   - Patients on strong CYP3A4 inhibitors

   - Uncorrected abnormal electrolytes- K, Mg and Ca

   - Treatment with any of the following anti-cancer therapies:

   - o radiation therapy, surgery or tumor embolization within 14 days prior to the first
   dose of pazopanib OR

   - o chemotherapy, immunotherapy, biologic therapy, investigational therapy or hormonal
   therapy within 14 days or five half-lives of a drug (whichever is longer) prior to the
   first dose of pazopanib


drug: Pazopanib

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305

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