Personal Genomics for Preventive Cardiology

Inclusion Criteria:

* Adults age \> 18
* Patient seeking cardiovascular risk evaluation
* At intermediate (6-20%) or high risk (\> 20%) over 10 years of CAD as defined by Framingham 10 year risk score AND/OR at \> 20% risk of CAD over 30 years using the Framingham 30 year risk calculator
* The genetic risk factors have been evaluated predominantly in white/European subjects. However, there is considerable overlap in the genetic architecture of South Asians and Hispanic/Latino populations. Therefore, we will limit our initial studies to these three race/ethnicity groups.

Exclusion Criteria:

* History of myocardial infarction, angina, stroke, peripheral arterial disease, PCI, or CABG
* Already on lipid lowering therapy
* Anticipated survival \<1 year (e.g. metastatic cancer)
* Serious conditions that would limit ability to adhere to recommendations (inability to take statins, exercise)
* Already had genetic testing
* Concurrent enrollment in another clinical trial
* Pregnant or breastfeeding