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Not Recruiting
Trial ID: NCT01406808
A Pilot Randomized Trial of Personal Genomics for Preventive Cardiology
Associate Dean, School of Medicine, Roger and Joelle Burnell Professor of Genomics and Precision Health, Professor of Medicine (Cardiovascular Medicine), of Genetics, of Biomedical Data Science and, by courtesy, of Pathology
Associate Professor of Medicine (Cardiovascular Medicine)
Inclusion Criteria:
- Adults age > 18
- Patient seeking cardiovascular risk evaluation
- At intermediate (6-20%) or high risk (> 20%) over 10 years of CAD as defined by
Framingham 10 year risk score AND/OR at > 20% risk of CAD over 30 years using the
Framingham 30 year risk calculator
- The genetic risk factors have been evaluated predominantly in white/European subjects.
However, there is considerable overlap in the genetic architecture of South Asians and
Hispanic/Latino populations. Therefore, we will limit our initial studies to these
three race/ethnicity groups.
Exclusion Criteria:
- History of myocardial infarction, angina, stroke, peripheral arterial disease, PCI, or
CABG
- Already on lipid lowering therapy
- Anticipated survival <1 year (e.g. metastatic cancer)
- Serious conditions that would limit ability to adhere to recommendations (inability to
take statins, exercise)
- Already had genetic testing
- Concurrent enrollment in another clinical trial
- Pregnant or breastfeeding
behavioral: genetic risk score for coronary risk factors
Not Recruiting
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Josh Knowles
650-804-2526