Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects

Inclusion Criteria:

* PSC Diagnosis: Liver biopsy and/or imaging (MRCP, ERCP, CT, or US
* Colonoscopy within 1 year or starting of study
* 2 groups:

1. IBD (Inflammatory bowel disease) and PSC: details of extent and type of IBD
2. No IBD and PSC, but positive p-ANCA or ASCA serologies indicating possible IBD.

Exclusion Criteria:

* Allergy to Vancomycin
* PSC not associated with IBD or NO positive IBD antibodies (p-ANCA \[anti- neutrophil cytoplasmic antibody\] or ASCA \[anti-Saccharomyces cerevisiae antibody\])
* Cholangiocarcinoma
* On oral or topical (enemas or suppositories) corticosteroids,topical mesalamine, or biologics (infliximab, adalimumab, certolizumab).