Pivotal Response Treatment Package for Young Children With Autism

Not Recruiting

Trial ID: NCT02037022


This is a research study examining the effectiveness of a pivotal response treatment package (PRT-P) in targeting language skills in young children with autism.

Official Title

Pivotal Response Treatment Package for Young Children With Autism

Stanford Investigator(s)

Antonio Hardan, M.D.
Antonio Hardan, M.D.

Professor of Psychiatry and Behavioral Sciences


Inclusion Criteria:

   - Diagnosis of Autism Spectrum Disorder (ASD) based on Autism Diagnostic Interview-
   Revised (ADI-R), Autism Diagnostic Observation Schedule (ADOS-2), and expert clinical

   - Males and females in good medical health between 2.0 and 5.11 years

   - Ability to participate in the testing procedures to the extent that valid standard
   scores can be obtained

   - Language delay as measured by the Preschool Language Scale: Standard score at least 1
   Standard Deviation below average for expressive language ability

   - Stable treatment, speech therapy, school placement, psychotropic medication(s) or
   biomedical intervention(s) for at least 1 month prior to baseline measurements with no
   anticipated changes during study participation

   - No more than 60 minutes of individual 1:1 speech therapy per week

   - Availability of at least one parent who can consistently participate in parent
   training and research measures

   - Parents intend on continuing Pivotal Response Treatment Package (PRT-P) for a minimum
   of 12 weeks

   - Parents must be 18 years of age or older

Exclusion Criteria:

   - Current or lifetime diagnosis of severe psychiatric disorder, such as bipolar disorder

   - Receiving in-home Applied Behavior Analysis (ABA) of 10 hours or more

   - A genetic abnormality, such as Fragile X

   - Presence of active medical problem, such as unstable seizure disorder or heart disease

   - Previous adequate PRT trial

   - Participants living more than 50 miles from Stanford University

   - At least one room of the house must be available to be dedicated to treatment during
   session times

   - There must be no serious health and safety risks present in the home environment

   - The research team has the right to refuse to perform sessions in-home even if the
   criteria above are met


behavioral: Pivotal Response Treatment Package (PRT-P)

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Rachel Schuck, BA