PIEB vs CEI for Labor Analgesia: An MLAC Study

Not Recruiting

Trial ID: NCT02573597


Utilizing a 'minimal local analgesic concentration (MLAC) study' design to first determine the relative potency of Programmed Intermittent Epidural Bolus (PIEB) compared to Continuous Epidural Infusion (CEI) and secondly to determine the mechanism to explain the potential PIEB efficacy advantage.

Official Title

Programmed Intermittent Epidural Bolus (PIEB) Compared to Continuous Epidural Infusion (CEI) Relative Efficacy and Mechanism of Efficacy For Labor Anlagesia: A Minimal Local Analgesic Concentration (MLAC) Study

Stanford Investigator(s)

Brendan Carvalho
Brendan Carvalho

Professor of Anesthesiology, Perioperative and Pain Medicine (Adult MSD) and, by courtesy, of Obstetrics and Gynecology (Maternal Fetal Medicine)


Inclusion Criteria:

   - ASA I & II, Nulliparous and Multiparous, Spontaneous/Induced/Augmented Labor, Early
   active labor (cervix <5 cm (if known)), Pain (VPS) > 3, 18-45 years of age

Exclusion Criteria:

   - <37 weeks gestation, H/o Cesarean Section, Multiple Gestation, Pre-eclampsia,
   Narcotics within 3 hours prior to labor epidural placement, Chronic Pain (as defined
   by chronic opiate consumption), Women who are participating in another study that will
   impact protocol


drug: Bupivacaine

drug: Sufentanil

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Aramina Aksamit, RN