©2022 Stanford Medicine
Protective Mechanisms Against a Pandemic Respiratory Virus (SLVP024)
Trial ID: NCT03023683
The purpose of the study is to investigate and compare the human immune response in epithelial cells of the nasopharyngeal mucosa and in blood to live, attenuated influenza vaccine (LAIV) in adults and in children.
U19 Influenza Immunity: Protective Mechanisms Against a Pandemic Respiratory Virus. Project 1: B-cell Immunity to Influenza
1. Otherwise healthy, ambulatory 2-8 years old (Group A) or 18-49 years old (Group B).
2. Willing to complete the informed consent process (including assent for minors 7 years
old and above).
3. Availability for follow-up for the planned duration of the study at least 28 days
4. Acceptable medical history by review of inclusion and exclusion criteria and vital
1. Prior off-study vaccination with the current 2012-2013 seasonal TIV or LAIV.
2. Allergy to egg or egg products, or to vaccine components, including gentamicin,
gelatin, arginine or MSG (LAIV)
3. Life-threatening reactions to previous influenza vaccinations
4. Asthma or history of wheezing
5. Active systemic or serious concurrent illness, including febrile illness on the day of
6. History of immunodeficiency (including HIV infection)
7. Known or suspected impairment of immunologic function, including, but not limited to,
clinically significant liver disease, diabetes mellitus treated with insulin, moderate
to severe renal disease, or any other chronic disorder which, in the opinion of the
investigator, might jeopardize volunteer safety or compliance with the protocol.
8. Blood pressure >150 systolic or >95 diastolic at the first study visit and on the day
9. Hospitalization in the past year for congestive heart failure or emphysema.
10. Chronic Hepatitis B or C.
11. Recent or current use of immunosuppressive medication, including systemic
glucocorticoids (corticosteroid nasal sprays and topical steroids are permissible in
all groups; inhaled steroid use is not permissible)
12. Participants in close contact with anyone who has a severely weakened immune system
should not receive LAIV
13. Malignancy, other than squamous cell or basal cell skin cancer (includes solid tumors
such as breast cancer or prostate cancer with recurrence in the past year, and any
hematologic cancer such as leukemia).
14. Autoimmune disease (including rheumatoid arthritis treated with immunosuppressive
medication such as Plaquenil, methotrexate, prednisone, Enbrel) which, in the opinion
of the investigator, might jeopardize volunteer safety or compliance with the
15. History of blood dyscrasias, renal disease, or hemoglobinopathies requiring regular
medical follow up or hospitalization during the preceding year
16. Use of any anti-coagulation medication such as Coumadin or Lovenox, or anti-platelet
agents such as aspirin (except up to 325 mg. per day), Plavix, or Aggrenox must be
reviewed by investigator to determine if this would affect the volunteer's safety.
17. Receipt of blood or blood products within the past 6 months or planned used during the
18. Medical or psychiatric condition or occupational responsibilities that preclude
participant compliance with the protocol
19. Receipt of Inactivated vaccine 14 days prior to study enrollment, or planned
vaccinations prior to completion of last visit ( Day ~28 after study vaccination)
20. Receipt of live, attenuated vaccine within 60 days prior to enrollment of planned
vaccination prior to completion of last visit (Day ~28 after study vaccination)
21. Need for allergy immunization (that cannot be postponed) during the study period.
22. History of Guillain-Barré syndrome
23. Pregnant or lactating woman (NA for children in Group A)
24. Use of investigational agents within 30 days prior to enrollment or planned use during
25. Donation of the equivalent of a unit of blood within 6 weeks prior to enrollment or
planned donation prior to completion of the last visit.
26. A current member of the clinical study team.
27. Any condition which, in the opinion of the investigator, might interfere with
volunteer safety, study objectives or the ability of the participant to understand or
comply with the study protocol.
School of Medicine
300 Pasteur Drive
Stanford, CA 94305