Latest1 information on COVID-19
©2022 Stanford Medicine
Not Recruiting
Trial ID: NCT03733210
Pilot Study Evaluating Panitumumab-IRDye800 and 89Zr-Panitumumab for Dual-Modality Imaging for Nodal Staging in Head and Neck Cancer
Inclusion Criteria:
- Biopsy confirmed diagnosis of squamous cell carcinoma of the head and neck.
- Subjects diagnosed with any T stage, any subsite within the head and neck that are
scheduled to undergo surgical resection. Subjects with recurrent disease or a new
primary will be allowed.
- Planned standard of care surgery with curative intent for squamous cell carcinoma.
- Hemoglobin ≥ 9 gm/dL.
- White blood cell count > 3000/mm³.
- Platelet count ≥ 100,000/mm³.
- Serum creatinine ≤ 1.5 times upper reference range.
Exclusion Criteria:
- Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive
heart failure (CHF); significant liver disease; or unstable angina within 6 months
prior to enrollment.
- Previous bilateral neck dissection.
- History of infusion reactions to monoclonal antibody therapies.
- Pregnant or breastfeeding.
- Magnesium or potassium lower than the normal institutional values.
- Subjects receiving class IA (quinidine, procainamide) or class III (dofetilide,
amiodarone, sotalol) antiarrhythmic agents.
- Subjects with a history or evidence of interstitial pneumonitis or pulmonary fibrosis.
- Severe renal disease or anuria.
- Known hypersensitivity to deferoxamine or any of its components.
drug: Panitumumab-IRDye800
drug: Zirconium Zr-89 Panitumumab
device: Pinpoint IR IR9000 flourescence imaging system (FIS)
device: SPY-PHI IR9000 flourescence imaging system (FIS)
device: Explorer Air camera
device: PDE-NEO II camera
device: FIS-00 fluorescence imaging system (FIS)
device: Da Vinci Firefly Imaging System
device: IGP-ELVIS-v4 Macroscopic Specimen Imager
device: Vevo 3100 LAZR-X
device: Pearl Triology Imaging System
device: Odyssey CLx Imaging System
device: Leica fluorescence microscope
Not Recruiting
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Alexander Ayon Valencia
650-498-5185