Perinatal Arterial Stroke: a Multi-site RCT of Intensive Infant Rehabilitation (I-ACQUIRE)

Inclusion Criteria:

* child will be 8 - 36 months old when study treatment will be delivered
* child has a diagnosis of Perinatal Arterial Stroke (PAS)
* parent permission to provide the child's clinical MRI to the study
* child has hemiparesis
* parent(s) willing to participate in the home therapy component
* one parent English language proficient and will take the lead in interacting with study staff and completing self-administered forms and interviews in English

Exclusion Criteria:

* child has medical or sensory condition(s) that prevent(s) full therapy participation (e.g., frequent uncontrolled seizures, fragile health)
* child previously received Constraint-Induced Movement Therapy (CIMT) or modified CIMT with a dose of at least 2 hrs/day for ≥10 days
* child received botulinum toxin in past 3 months
* child is a ward of the state or other agency