Predicting Endometrial Receptivity for Optimal Reproductive Management

Not Recruiting

Trial ID: NCT04107129


The purpose of this study is to understand why some women are infertile (unable to conceive a child). The investigators hope to learn if an endometrial biopsy after egg retrieval is feasible for detecting biomarkers for endometriosis and predicting implantation and pregnancy rate after embryo transfer. This study design will provide for the first time, an opportunity to compare endometrial biopsy material from hyperstimulated (gonadotropin treated) subjects after egg retrieval. If successful, it would provide a new protocol for women with unexplained infertility or those with known endometriosis to avoid poor IVF outcomes.

Official Title

Predicting Endometrial Receptivity for Optimal Reproductive Management (PERFORM)

Stanford Investigator(s)

Ruth Lathi, M.D.
Ruth Lathi, M.D.

Professor of Obstetrics and Gynecology (Reproductive Endocrinology and Infertility)


Inclusion Criteria:

   1. Age - 18 to 42

   2. AMH ≥ 1

   3. Planning to undergo IVF with delayed embryo transfer

   4. Must have blastocyst(s) by day 6 that were biopsied for PGT-A

   5. BMI 18-35

Exclusion Criteria:

   1. Uterine fibroids > 4 cm in size

   2. Polycystic ovary syndrome (PCOS) according with the Rotterdam criteria.

   3. Ovarian failure and subjects receiving donor oocytes/embryos

   4. Anti-cardiolipid and/or lupus anti-coagulant abnormalities by history

   5. Diabetes mellitus (Type I or Type II)

   6. Untreated hypothyroidism

   7. Hyperprolactinemia

   8. Uncorrected uterine anomaly


diagnostic test: Blood sample

procedure: Endometrial Biopsy

other: Euploid embryo transfer

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Raquel Fleischmann, DVM