PET/MRI in the Diagnosis of Pediatric Chronic Pain


Trial ID: NCT04435821


[18F]FTC-146 is a sigma-1 receptor detector and is an experimental radiotracer. Several studies have implicated involvement of sigma-1 receptors in generation and perpetuation of chronic pain conditions, while others are investigating anti sigma-1 receptor drugs for treatment of chronic pain. Using [18F]-FTC-146 and PET/MRI, we hope to learn what is the best approach to identify the source of pain generation and characterize the disease in pediatric patients with chronic pain.

Official Title

Use of PET/MRI in the Diagnosis of Pediatric Chronic Pain

Stanford Investigator(s)

Helen Nadel

Clinical Professor, Radiology - Pediatric Radiology


Inclusion Criteria:

   - 11-18 years old.

   - Chronic pain (nociceptive, neuropathic or mixed pain) lasting at least 2 months.

   - Pain level of at least 4/10 on a 0-10 Comparative Pain Scale (reported at time of

   - Covid Vaccination status: Vaccinated or unvaccinated subjects who received a negative
   test result from the Covid test within 72 hours of the scan.

Exclusion Criteria:

   - MRI incompatible

   - Pregnant or nursing

   - Non-English speaker

   - Claustrophobic


drug: [18F]FTC-146


Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305