Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone


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Trial ID: NCT04676802


In the US, pain management after surgery for surgical treatment of osteoarthritis at the base of the thumb typically consists of prescription opioids during the early recovery phase. Given the highly addictive nature of prescription opioids, guidelines are being evaluated by hand surgeons to reduce opioid use while still maintaining pain control after surgery. A promising approach is to use non-narcotic medication as the first line of treatment. The purpose of this study is to demonstrate the efficacy of a combination of non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen and acetaminophen, in comparison to a morphine analogue substance (oxycodone) for pain management in the first 30 days after surgery.

Official Title

Pain Relief After Trapeziectomy Without Opioids: Ibuprofen & Acetaminophen Versus Oxycodone

Stanford Investigator(s)

Amy Ladd, MD
Amy Ladd, MD

Elsbach-Richards Professor of Surgery and Professor, by courtesy, of Medicine (Immunology & Rheumatology) and of Surgery (Plastic and Reconstructive Surgery)


Inclusion Criteria:

   - Undergoing trapeziectomy for thumb osteoarthritis

English proficient,

Exclusion Criteria:

   - Pregnancy

Current use of opioids

Concurrent surgeries (ex. trapeziectomy combined with carpal tunnel release)

Inability to complete study forms (education, cognitive ability, mental status, medical

Allergy or intolerance to Ibuprofen, Acetaminophen and/or Oxycodone

Liver or kidney dysfunction, abnormal liver enzymes restricting use of acetaminophen or

History of chronic heart failure, upper gastrointestinal bleeding or coagulopathy

History of complex regional pain syndrome


drug: Opioid capsule

drug: NSAID capsules


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Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305