Reproductive Function and Mood in Women With Bipolar Disorder

Not Recruiting

Trial ID: NCT00183352


This study will determine the effect of medication for bipolar disorder on the reproductive function and whether mood changes occur during the menstrual cycle in women with bipolar disorder.

Official Title

Reproductive Endocrine Function and Mood Over the Menstrual Cycle of Women Treated for Bipolar Disorder

Stanford Investigator(s)


Inclusion Criteria for All Participants:

   - Have been menstruating for at least 4 years prior to study entry

   - Participants must be willing to travel to Stanford University at own expense for study

Inclusion Criteria for Bipolar Disorder Participants:

   - Participants should have a diagnosis of Bipolar I, Bipolar II, or Bipolar not
   otherwise specified (NOS), and be under the treatment of a physician who can be
   contacted in case of an emergency

   - Current treatment with any mood-stabilizing agent for a period of at least 3 months
   (e.g., divalproex sodium, lithium, other mood stabilizer, or atypical antipsychotic)

Inclusion Criteria for Healthy Controls:

   - No past or present diagnosis of mental illness

Exclusion Criteria for All Participants:

   - Current alcohol or substance abuse or dependence within 6 months prior to study entry

   - Meets criteria for another DSM-IV Axis I disorder

   - Contraceptive steroid use within 3 months prior to study entry

   - Current use of medication that may affect steroid metabolism

   - Menopausal

   - Endocrine disease such as diabetes or hypothyroidism

   - Uncontrolled medical illness

   - History of long-term corticosteroid use

   - Organic mood disorder

   - Pregnancy or breastfeeding within 3 months prior to study entry

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305