Rare Genetic Disorders of the Breathing Airways

Inclusion Criteria:

   - Received a standard diagnostic evaluation prior to study entry that resulted in one of
   the following three profiles:

      1. High likelihood of PCD diagnosis, based on ciliary ultrastructural changes seen
      on electron microscopy or clinical features (chronic sinopulmonary disease,
      chronic otitis media, history of neonatal respiratory distress or situs inversus)
      OR one clinical feature of PCD and a sibling with PCD

      2. Chronic sino-pulmonary disease with clinical features that overlap with variant
      CF and PCD, but with diagnostic tests that rule out classical CF (sweat chloride
      testing and CF gene mutation screening)

      3. Known or suspected PHA (or variant PHA), possibly including elevated (or
      borderline) sweat chloride values

Exclusion Criteria:

   - Has not received a standard clinical evaluation to rule out other disorders associated
   with chronic sino-pulmonary disease