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Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea
Not Recruiting
Trial ID: NCT00672737
Purpose
We would like to test the effect of opioid medication on pain sensitivity in subjects who
have been diagnosed with a sleep disorder called Obstructive Sleep Apnea (OSA) compared to
other subjects without OSA. Patients with OSA may have an altered sensitivity to the
sedative, analgesic, and respiratory depressant effects of opioids.
Official Title
Experimental Pain Processing and Autonomic Function in Subjects Suffering From Obstructive Sleep Apnea
Stanford Investigator(s)
Anthony G. Doufas, M.D., Ph.D.
Professor of Anesthesiology, Perioperative and Pain Medicine
Eligibility
Inclusion Criteria:1. Male 2 .18 - 55 years of age 3. Body mass index (BMI) lower or equal
to 30 kg/m2 4. Absence of severe systemic disease that results in functional limitations
(i.e. poorly controlled hypertension, angina pectoris, prior myocardial infarction,
pulmonary disease that limits activity) 5.Subjects must be able to comprehend spoken and
written English
Exclusion Criteria:1. Major psychiatric, neurological, or neuromuscular disorder 2. Known
diabetes mellitus or thyroid disease 3. Allergy to study medication (remifentanil) 4.
History of addiction 5. Alcohol consumption which exceeds 2 drinks per day and /or drug
abuse. 6. Chronic or acute use of opioids, or other medications affecting the CNS.
Intervention(s):
drug: Remifentanil
procedure: Cold pain threshold and tolerance
device: Heat pain threshold and tolerance
procedure: Polysomnography
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305