Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea

Not Recruiting

Trial ID: NCT00672737

Purpose

We would like to test the effect of opioid medication on pain sensitivity in subjects who have been diagnosed with a sleep disorder called Obstructive Sleep Apnea (OSA) compared to other subjects without OSA. Patients with OSA may have an altered sensitivity to the sedative, analgesic, and respiratory depressant effects of opioids.

Official Title

Experimental Pain Processing and Autonomic Function in Subjects Suffering From Obstructive Sleep Apnea

Stanford Investigator(s)

Anthony G. Doufas, M.D., Ph.D.
Anthony G. Doufas, M.D., Ph.D.

Professor of Anesthesiology, Perioperative and Pain Medicine

Eligibility

Inclusion Criteria:1. Male 2 .18 - 55 years of age 3. Body mass index (BMI) lower or equal to 30 kg/m2 4. Absence of severe systemic disease that results in functional limitations (i.e. poorly controlled hypertension, angina pectoris, prior myocardial infarction, pulmonary disease that limits activity) 5.Subjects must be able to comprehend spoken and written English

Exclusion Criteria:1. Major psychiatric, neurological, or neuromuscular disorder 2. Known diabetes mellitus or thyroid disease 3. Allergy to study medication (remifentanil) 4. History of addiction 5. Alcohol consumption which exceeds 2 drinks per day and /or drug abuse. 6. Chronic or acute use of opioids, or other medications affecting the CNS.

Intervention(s):

drug: Remifentanil

procedure: Cold pain threshold and tolerance

device: Heat pain threshold and tolerance

procedure: Polysomnography

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305