Specialized Radiation Therapy in Treating Patients With Stage II, Stage III, Stage IV, or Recurrent Non-Small Cell Lung Cancer and Poor Performance Status

Not Recruiting

Trial ID: NCT00986297

Purpose

RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. PURPOSE: This phase I trial is studying the side effects and best dose of specialized radiation therapy in treating patients with stage II, stage III, stage IV, or recurrent non-small cell lung cancer and poor performance status.

Official Title

Phase 1 Study of Accelerated Hypofractionated Image-Guided Radiation Therapy (IGRT) in Patients With Stage II-IV Non-Small Cell Lung Cancer and Poor Performance Status

Stanford Investigator(s)

Billy W Loo, Jr, MD PhD FASTRO FACR
Billy W Loo, Jr, MD PhD FASTRO FACR

Professor of Radiation Oncology (Radiation Therapy)

Eligibility

DISEASE CHARACTERISTICS:

* Histologically or cytologically confirmed non-small cell lung cancer

* Stage II-IV and/or recurrent disease
* No small cell histology
* Measurable or evaluable disease

* Tumor not amenable to surgical resection
* Tumor not eligible for stereotactic body radiation therapy
* No prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields

PATIENT CHARACTERISTICS:

* Zubrod performance status 2-4
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must agree to use effective contraception
* Must complete all required pretreatment evaluations

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics
* More than 1 week since prior chemotherapy or chemoradiation therapy
* No concurrent chemotherapy
* No other concurrent antineoplastic therapy (including standard-fractionated radiotherapy to the chest, chemotherapy, biological therapy, vaccine therapy, and surgery) 1 week before, during, and for 1 week after completion of study therapy

Intervention(s):

radiation: hypofractionated radiation therapy

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Cancer Clinical Trials Office
650-498-7061

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