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Study of Drug Concentration of Ondansetron and Cefazolin in Mothers and Neonates
Not Recruiting
Trial ID: NCT01357369
Purpose
This study proposes to look at the pharmacokinetics of two drugs (Cefazolin and ondansetron)
given routinely to pregnant women who are planning to deliver via cesarean section. The
investigators will evaluate the metabolism of both drugs by the pregnant woman, the placental
transfer over time, and the subsequent metabolism of the transferred drug in the neonate.
Official Title
Pharmacokinetics and Placental Transfer of Ondansetron and Cefazolin: A Preliminary Analysis
Eligibility
Inclusion Criteria:
Adult participant:
- Age 18-45 years old
- Term pregnancy (37-42 weeks)
- Delivers by planned cesarean section, or unplanned, non-urgent cesarean section.
- Generally healthy
- Able and willing to sign informed consent
Neonatal participant:
- Male of female
- 37-42 weeks gestation
Exclusion Criteria:
- Adult:Medical condition that would effect metabolism of the study drugs
- Known allergy to either study medication
- Use of medications in the last 48 hours that might induce or inhibit metabolism of
ondansetron (e.g. barbiturates, fluconazole, erythromycin, etc.)
Intervention(s):
procedure: Phlebotomy
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Martha Tingle
6507242742