Stanford Universities: The Stanford HIV Aging Cohort

Not Recruiting

Trial ID: NCT01401348


A research study to evaluate the effect of aging and HIV on neurocognitive dysfunction (declining ability to process information), physical frailty and heart disease. HIV-infected participants whose virus is controlled on antiretroviral medications will be studied to determine the rates and risk factors of developing these conditions.

Official Title

The Stanford HIV Aging Cohort (SHAC)

Stanford Investigator(s)

Philip Grant
Philip Grant

Asst Prof-Univ Med Line, Medicine - Infectious Diseases


Inclusion Criteria:

   - Subjects must have an HIV RNA level below the limit of quantification (e.g., <75
   copies, <50 copies, or <48 copies/mL, depending on the assay used) for at least 6
   months excluding "blips" (e.g., a single measurement between 48-200 copies/mL preceded
   and followed by measurements below the limit of quantification) while on
   antiretroviral therapy.

Exclusion Criteria:

   1. Completed treatment for any acute systemic infection (other than HIV-1) less than four
   weeks before study entry.

   2. Any active brain infection (except for HIV-1), brain neoplasm, or space-occupying
   brain lesion.

   3. Receipt of immunomodulating medication (e.g., corticosteroids, immunoglobulin, etc.)
   within four weeks of study entry.

   4. Any active psychiatric illness including schizophrenia, severe depression, or severe
   bipolar affective disorder that, in the opinion of the investigator, could confound
   the analysis of the neuropsychological test results.

   5. Active drug or alcohol abuse that, in the investigator's opinion, could prevent
   compliance with study procedures or confound the analysis of study endpoints.

   6. Unable to provide informed consent

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Debbie Slamowitz