Study of HUCNS-SC Subretinal Transplantation in Subjects With GA of AMD

Not Recruiting

Trial ID: NCT02467634


A fellow eye controlled study of HUCNS-SC sub-retinal transplantation in subjects with bilateral GA AMD. All subjects will be assigned to HUCNS-SC transplantation.

Official Title

A Phase II Proof-of-Concept Study of the Safety and Efficacy of HUCNS-SC Subretinal Transplantation in Subjects With Geographic Atrophy of Age-Related Macular Degeneration

Stanford Investigator(s)

Theodore Leng, MD, FACS
Theodore Leng, MD, FACS

Associate Professor of Ophthalmology and, by courtesy, of Anesthesiology, Perioperative and Pain Medicine (Adult MSD)


Inclusion Criteria:

   - GA associated with AMD in both eyes. Total area of GA determined by fundus

   - BCVA of 20/320 or better in each eye at screening assessment

Exclusion Criteria:

   - Prior or concurrent choroidal neovascularization in either eye by clinical exam and/or
   fluorescein angiography as determined by the investigator or the reading center.

   - Retinal or macular disease of any other cause in either eye.

   - Diagnosis of glaucoma in either eye.

   - Uncontrolled intraocular pressure in either eye

   - Compromised renal function defined as eGFR <60mL/min and urine protein-to-creatinine
   ration >0.3 is spot urine collection.

   - History of or active autoimmune disease.

   - Previous organ, tissue or bone marrow transplantation.

   - Seropositive for HIV, hepatitis B or C, or CMV IgM


biological: HuCNS-SC sub-retinal transplantation

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305