Study of Refeeding to Optimize iNpatient Gains


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Trial ID: NCT02621229


The purpose of this study is to compare the efficacy, safety, and cost-effectiveness of lower calorie refeeding versus higher calorie refeeding in hospitalized adolescents with anorexia nervosa.

Official Title

Multi-center Randomized Controlled Trial of Refeeding in Anorexia Nervosa

Stanford Investigator(s)


Inclusion Criteria:

   - diagnosis of AN

   - atypical AN

   - no hospital admissions for the previous six months

   - meet hospitalization criteria: daytime heart rate (HR) < 50 bpm or night time HR < 45
   bpm, blood pressure (BP) <90/45 mmHg, temperature < 35.6° C, or symptomatic
   orthostasis defined by increase in HR > 35 bpm or decrease in systolic BP > 20 mmHg or
   decrease in diastolic BP > 10 mmHg from lying to standing

Exclusion Criteria:

   - diagnosis of bulimia nervosa [DSM-5]

   - currently in remission (as defined by weight and EDE-Q score)

   - admission for food refusal without malnutrition

   - current pregnancy

   - chronic disease (e.g. immune/endocrine disorders, pulmonary, cardiac, or renal

   - current suicidality or psychosis

   - < 60% mBMI


other: Higher Calorie Refeeding

other: Lower Calorie Refeeding


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Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Anna Kreiter
646 335-3035