Study to Evaluate the Efficacy & Safety of the INTERCEPT Blood System for RBCs in Complex Cardiac Surgery Patients


Trial ID: NCT03459287


The objective of this study is to evaluate the efficacy and safety of RBC transfusion for support of acute anemia in cardiovascular surgery patients based on the clinical outcome of renal impairment following transfusion of red blood cells (RBCs) treated with the INTERCEPT Blood System (IBS) for Red Blood Cells compared to patients transfused with conventional RBCs.

Official Title

A Randomized, Double-Blinded, Controlled, Parallel Group, Non-inferiority, Phase III Study to Evaluate the Efficacy and Safety of the INTERCEPT Blood System for Red Blood Cells in Patients Undergoing Complex Cardiac Surgery Procedures

Stanford Investigator(s)

Anil K. Panigrahi

Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine Clinical Associate Professor (By courtesy), Pathology

Ronald Pearl
Ronald Pearl

Dr. Richard K. and Erika N. Richards Professor


Inclusion Criteria:

   1. Age ≥ 11 years of age

   2. Weight ≥ 40 kg

   3. Scheduled complex cardiac surgery or thoracic aorta surgery. The procedure may be
   performed either on or off cardiopulmonary bypass machine (CBP or "pump"). For the
   purposes of this protocol "Repeat procedure" means that the subject had a previous
   cardiac surgery. Procedures that qualify as complex cardiac surgery include but are
   not limited to, the following:

      - Single Vessel Coronary Artery Bypass Graft, first or repeat procedure

      - Multiple Coronary Artery Bypass Grafts, first or repeat procedure

      - Single Valve Repair or Replacement, first or repeat procedure

      - Multiple Valve Repair or Replacement, first or repeat procedure

      - Surgery involving both Coronary Artery Bypass Graft(s) and Valve Repair(s), first
      or repeat procedure

      - One or more of the following procedures, with or without Coronary Bypass

         - left ventricular aneurysm repair

         - ventricular and/or atrial septal defect repairs

         - Batista procedure (surgical ventricular remodeling)

         - surgical ventricular restoration

         - congenital cardiac defect repair

         - aortic procedures

         - other cardiac surgery or thoracic aorta surgery types with a high
         probability of bleeding

   4. TRUST probability score (Alghamdi, Davis et al. 2006) ≥ 3, or currently on a regimen
   of aspirin (any dose), clopidogrel (or analogs) and/or GPIIb/IIIa inhibitors or at a
   high probability for need of a transfusion during or after surgery at the discretion
   of the Investigator

   5. Female subjects of child-bearing potential must meet the 2 criteria below at

      - Negative serum or urine pregnancy test

      - Use at least one method of birth control that results in a low failure rate
      (i.e., less than 1% per year) when used consistently and correctly such as
      implants, injectables, combined oral contraceptives, some intrauterine devices
      (IUDs), sexual abstinence or vasectomized partner

   6. Signed and dated informed consent/assent form

Exclusion Criteria:

   1. Confirmed positive baseline serum/plasma antibody specific to INTERCEPT RBCs (S-303
   specific antibody) screening panel prior to randomization.

   2. Pregnant or breast feeding

   3. Refusal of blood products or other inability to comply with the protocol in the
   opinion of the Investigator or the treating physician

   4. Treatment with any medication that is known to adversely affect RBC viability, such
   as, but not limited to dapsone, levodopa, methyldopa, nitrofurantoin, and its
   derivatives, phenazopyridine and quinidine.

   5. Planned cardiac transplantation

   6. Active autoimmune hemolytic anemia

   7. Left ventricular assist device (LVAD) or extracorporeal membrane oxygenation (ECMO)
   support pre operatively or planned need post-operatively

   8. Cardiogenic shock requiring pre-operative placement of an intra-aortic balloon pump
   (IABP) (NOTE: IABP done for unstable angina or prophylactically for low ejection
   fraction is not excluded).

   9. Planned use of autologous or directed donations.

10. RBC transfusion during current hospitalization prior to enrollment and randomization
   (within 7 days).

11. Participation in an interventional clinical study concurrently or within the previous
   28 days. This includes investigational blood products, pharmacologic agents, imaging
   materials (including dyes), surgical techniques, or devices. Observational studies of
   FDA cleared or approved products or nutrition, psychology, or socioeconomic issues are
   not grounds for exclusion

12. Patients with a current diagnosis of either chronic kidney disease or acute kidney
   injury and with sCr ≥1.8 mg/dL at screening and patients requiring RRT. (NOTE: If sCr
   at screening is <1.8 mg/dL, a patient with a diagnosis of chronic or acute kidney
   injury alone is not excluded).

13. Patients with a current diagnosis of either chronic or acute hepatic insufficiency and
   with a total serum bilirubin ≥ 2.0 mg/dL (≥34.2 µmol/L). (NOTE: If total serum
   bilirubin at screening is <2.0 mg/dL, a patient with a diagnosis of chronic or acute
   hepatic failure alone is not excluded).

14. Pre-existing antibody(ies) to RBC antigens that may make the provision of compatible
   study RBC components difficult.

15. History of TRs requiring washed RBCs, volume reduced RBC, or RBCs with additive
   solution removed.

16. Patients with documented IgA deficiency or a history of severe allergic reactions to
   blood products.

17. Patients who require gamma-irradiated RBC blood components.

18. Positive DAT as defined below:

A polyspecific DAT reaction strength > 2+, or

A polyspecific DAT (any strength) in conjunction with pan-reactivity with a commercial IAT
antibody screening panel that precludes the identification of underlying alloantibodies or
indicates the presence of autoantibody



device: Control


Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Ronald Pearl, Dr