SWAP-MEAT: Study With Appetizing Plant Food - Meat Eating Alternatives Trial

Inclusion Criteria:

* Age ≥18
* Meat consumption (beef, pork/sausage, chicken) on average ≥ once a day
* Willing to consume meat (beef, pork/sausage, chicken) ≥ 2 times a day

Exclusion Criteria:

* Weight \< 110 lb
* BMI ≥ 40
* LDL-C \>190 mg/dL
* Systolic blood pressure (SBP) \> 160 mmHg OR Diastolic blood pressure (DBP) \> 90 mmHg
* Use of any of the following drugs/supplements within the last 2 months:

* systemic antibiotics, antifungals, antivirals or antiparasitics (intravenous, intramuscular, or oral);
* corticosteroids (intravenous, intramuscular, oral, nasal or inhaled);
* cytokines;
* methotrexate or immunosuppressive cytotoxic agents;
* Chronic, clinically significant, or unstable (unresolved, requiring on-going changes to medical management or medication) pulmonary, cardiovascular, gastrointestinal, hepatic or renal functional abnormality, as determined by medical history, Type 1 diabetes, dialysis.
* History of active cancer in the past 3 years except for squamous or basal cell carcinomas of the skin that have been medically managed by local excision.
* Unstable dietary history as defined by major changes in diet during the previous month, where the subject has eliminated or significantly increased a major food group in the diet.
* Recent history of chronic excessive alcohol consumption defined as more than five 1.5-ounce servings of 80 proof distilled spirits, five 12-ounce servings of beer or five 5-ounce servings of wine per day; or \> 14 drinks/week.
* Any confirmed or suspected condition/state of immunosuppression or immunodeficiency (primary or acquired) including HIV infection, multiple sclerosis and Graves' disease.
* Regular/frequent use of smoking or chewing tobacco, e-cigarettes, cigars or other nicotine-containing products.
* Regular use of prescription opiate pain medication