Study Evaluating Sodium Selenite in Combination With Abiraterone in Castrate Resistant Prostate Cancer Progressing on Abiraterone

Not Recruiting

Trial ID: NCT04296578


The purpose of this study is to access the safety of combining sodium selenite with abiraterone and to see what doses of sodium selenite can be safely combined with abiraterone in treating castration resistant prostate cancer.

Official Title

A Phase 1 Study Evaluating the Efficacy and Safety of Sodium Selenite in Combination With Abiraterone in Patients With Castrate Resistant Prostate Cancer Progressing on Abiraterone

Stanford Investigator(s)


Inclusion Criteria:

   - Each subject must sign an informed consent form (ICF) indicating that he understands
   the purpose of and procedures required for the study and is willing to participate in
   the study. Consent is to be obtained prior to the initiation of any study related
   tests or procedures that are not part of standard of care for the subject's disease.

   - Histologically confirmed adenocarcinoma of the prostate with metastatic disease.

   - Progression on abiraterone defined by a rise in PSA at 2 time points at least 1 week

   - Male ≥18 years of age.

   - Prior orchiectomy or serum testosterone levels < 50 ng/dL determined within 4 weeks
   prior to start of study drug

   - Adequate baseline organ function as defined below:

      - Hemoglobin > 9 with or without transfusion

      - Platelets > 75 with or without transfusion

      - Neutrophil: Absolute neutrophil > 1.0

      - T bilirubin < 1.5 x Upper limit normal (ULN)

      - Aspartate aminotransferase (AST)/Alanine Aminotransferase (ALT) < 2.5 x ULN

      - Creatinine < 1.5 x ULN

   - Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 within 2 weeks
   of initiation of study drug administration.

   - Ongoing androgen depletion therapy with a gonadotropin releasing hormone (GnRH) analog
   or inhibitor, or orchiectomy (ie, surgical or medical castration). Note: subjects who
   have not undergone orchiectomy must continue GnRH analog therapy for the duration of
   this protocol.

   - For subjects previously treated with 1st generation anti androgens (ie, flutamide,
   nilutamide, or bicalutamide), discontinuation of flutamide or nilutamide therapy must
   occur > 4 weeks (> 6 weeks for bicalutamide) prior to start of study drug with no
   evidence of an anti androgen withdrawal response (ie, no decline in serum PSA; within
   6 weeks of last dose for bicalutamide and 4 weeks of last dose for all other drugs as

   - For subjects previously treated with chemotherapy, targeted therapy, immunotherapy, or
   treatment with an investigational anticancer agent, discontinuation must have occurred
   ≥ 2 weeks, or after at least 4 half lives, whichever is longer, prior to study drug
   administration. For enzalutamide and apalutamide, the washout period will be at least
   3 weeks prior to start of study drug with no evidence of an anti androgen withdrawal
   response (ie, no decline in serum PSA within 4 weeks of last dose.)

   - For subjects previously treated with other agents approved for the treatment of
   prostate cancer (5 α reductase inhibitors, estrogens, others), discontinuation of
   therapy must have occurred ≥ 4 weeks prior to start of study drug. This does not apply
   to abiraterone.

   - Palliative radiotherapy (to bone or soft tissue lesions) must be completed > 2 weeks
   prior to start of study drug.

   - For subjects receiving bone-loss prevention treatment (eg, bisphosphonates or
   denosumab), the subject must be on stable dose ≥ 4 weeks prior to start of study drug.

   - QT interval corrected using Fridericia's method (QTcF) less than 460 msec (see
   Appendix B for Fridericia's criteria).

   - A man who is sexually active with a woman of childbearing potential must agree to use
   an adequate method of contraception to avoid conception during the study and for 120
   days after receiving the last dose of study drug. All men must also not donate sperm
   during the study and for 120 days after receiving the last dose of study drug.

   - Subject must be willing and able to adhere to the prohibitions and restrictions
   specified in this protocol.

Exclusion Criteria:

   - Previously documented or current brain metastases.

   - Untreated spinal cord compression.

   - Known positive test result for human immunodeficiency virus.

   - History of clinically significant cardiovascular disease including, but not limited

      - Myocardial infarction or unstable angina within the 6 months prior to the first
      dose of study drug.

      - Clinically significant cardiac arrhythmia.

      - Uncontrolled (persistent) hypertension: systolic blood pressure > 180 mHg;
      diastolic blood pressure >100 mmHg.

      - Congestive heart failure (New York Heart Association class III IV).

   - Known active or chronic hepatitis B or hepatitis C as demonstrated by hepatitis B
   surface antigen positivity and/or anti hepatitis C virus positivity, respectively.
   Subjects with clinically active or chronic liver disease, including liver cirrhosis of
   Child Pugh class C, are also excluded.

   - History of a different malignancy except for the following circumstances: (a)
   individuals with a history of other malignancies are eligible if they have been
   disease free for at least 3 years and are deemed by the investigator to be at low risk
   for recurrence of that malignancy, (b) individuals with a history of treatment for the
   following cancers are eligible: non muscle invasive bladder cancer, basal cell, or
   squamous cell carcinoma of the skin and resected melanoma in situ.

   - Any serious underlying medical or psychiatric condition (eg, alcohol or drug abuse),
   dementia or altered mental status or any issue that would impair the ability of the
   subject to receive or tolerate the planned treatment, to understand informed consent
   or that in the opinion of the investigator would contraindicate the subject's
   participation in the study or that would confound the results of the study.

   - Evidence of active viral, bacterial, or systemic fungal infection requiring systemic
   treatment within 7 days prior to the first dose of study drug. Subjects requiring any
   systemic antiviral, antifungal, or antibacterial therapy for active infection must
   have completed treatment no less than 7 days prior to the first dose of study drug.

   - Enrollment in another therapeutic study.

   - Major surgery (eg, requiring general anesthesia) within 3 weeks before screening, or
   has not fully recovered from prior surgery (ie, unhealed wound), or surgery planned
   during the time the subject is expected to participate in the study. Note: subjects
   with planned surgical procedures to be conducted under local anesthesia may


drug: Abiraterone Acetate

drug: Sodium Selenite

drug: Prednisone

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Rachel A Freiberg