Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

Inclusion Criteria:

   - Expanded Disability Status Scale (EDSS) score of 0 - 5.5 at screening.

   - A diagnosis of RMS in accordance with the revised 2017 McDonald Criteria.

   - Ability to complete the 9-Hole Peg Test (9-HPT) for each hand in < 240 seconds.

   - Ability to perform the Timed 25-Foot Walk Test (T25FWT) in <150 seconds.

   - For female participants of childbearing potential: agreement to remain abstinent
   (refrain from heterosexual intercourse) or use contraceptive measures, and refrain
   from donating eggs.

   - For male participants: agreement to remain abstinent (refrain from heterosexual
   intercourse) or use contraceptive measures, and refrain from donating sperm.

Exclusion Criteria:

   - Disease duration of > 10 years from the onset of symptoms and an EDSS score at
   screening < 2.0.

   - Female participants who are pregnant or breastfeeding, or intending to become
   pregnant.

   - Male participants who intend to father a child during the study.

   - A diagnosis of primary progressive MS (PPMS) or non-active secondary progressive MS
   (SPMS).

   - Any known or suspected active infection at screening, including but not limited to a
   positive screening tests for Hepatitis B and C, an active or latent or inadequately
   treated infection with tuberculosis (TB), a confirmed or suspected progressive
   multifocal leukoencephalopathy (PML).

   - History of cancer including hematologic malignancy and solid tumors within 10 years of
   screening.

   - Known presence of other neurological disorders, that could interfere with the
   diagnosis of MS or assessments of efficacy or safety during the study and clinically
   significant cardiovascular, psychiatric, pulmonary, renal, hepatic, endocrine,
   metabolic or gastrointestinal disease.

   - Rare hereditary problems of galactose intolerance, total lactase deficiency, or
   glucose-galactose malabsorption.

   - Hypoproteinemia.

   - Presence of cirrhosis (Child-Pugh Class A, B, or C) or Gilbert's Syndrome.

   - Participants with significantly impaired bone marrow function or significant anemia,
   leukopenia, neutropenia or thrombocytopenia.

   - Any concomitant disease that may require chronic treatment with systemic
   corticosteroids or immunosuppressants during the course of the study.

   - History of alcohol or other drug abuse within 12 months prior to screening.

   - History of or currently active primary or secondary (non-drug-related)
   immunodeficiency, including known history of human immunodeficiency virus (HIV)
   infection.

   - Inability to complete an MRI scan.

   - Adrenocorticotropic hormone or systemic corticosteroid therapy within 4 weeks prior to
   screening (inhaled and topical corticosteroids are allowed).

   - Receipt of a live-attenuated vaccine within 6 weeks prior to randomization.

   - Any previous treatment with immunomodulatory or immunosuppressive medication without
   an appropriate washout period.

OLE Inclusion Criteria:

   - Completed the Double-Blind Treatment (DBT) phase of the study (remaining on study
   treatment; no other Disease-Modifying Therapy (DMT) administered) and who, in the
   opinion of the investigator, may benefit from treatment with fenebrutinib.

   - Participants randomized to the teriflunomide treatment arm during the DBT phase must
   undergo the accelerated teriflunomide elimination procedure (ATEP) prior to the first
   administration of open-label fenebrutinib.

   - For female participants of childbearing potential: agreement to remain abstinent
   (refrain from heterosexual intercourse) or use contraceptive measures, and refrain
   from donating eggs.

   - For male participants: agreement to remain abstinent (refrain from heterosexual
   intercourse) or use contraceptive measures, and refrain from donating sperm.