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The Effects of Staggered Dosing on Interactions Between Paired Combinations of Nelfinavir, Ritonavir, and Saquinavir
Not Recruiting
Trial ID: NCT00000898
Purpose
The purpose of this study is to see if staggering doses of nelfinavir, ritonavir, and
saquinavir has any effect on the interactions between these drugs.
Official Title
A Prototype Study to Test the Effect of Staggered Dosing on the Pharmacokinetic Interactions Between Paired Combinations of Nelfinavir (NFV), Ritonavir (RTV), and Soft Gelatin Capsule of Saquinavir (SQVsgc)
Eligibility
Inclusion Criteria
Patients must have:
- Absence of HIV-1 infection as documented by any licensed ELISA test kit within 14 days
prior to study entry.
Exclusion Criteria
Co-existing Condition:
Patients with the following symptoms and conditions are excluded:
- Any medical condition that, in the opinion of the investigator, would interfere with
the patient's ability to participate in this protocol.
Patients with the following prior conditions and symptoms are excluded:
- History of chronic illness such as hypertension, coronary artery disease, arthritis,
diabetes, or any chronic gastrointestinal conditions that might interfere with drug
absorption.
Intervention(s):
drug: Ritonavir
drug: Nelfinavir mesylate
drug: Saquinavir
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305