Treatment of Refractory Metastatic Renal Cell Carcinoma With Bevacizumab and RAD001 (Everolimus)

Not Recruiting

Trial ID: NCT00651482


To determine the safety and efficacy of the combination of bevacizumab and everolimus (RAD001) for the treatment of metastatic renal cell cancer

Official Title

Treatment of Refractory Metastatic Renal Cell Carcinoma With Bevacizumab and RAD001 (Everolimus)

Stanford Investigator(s)

Sandy Srinivas
Sandy Srinivas

Professor of Medicine (Oncology) and, by courtesy, of Urology


Inclusion Criteria:

   - Signed Informed Consent Form

   - Histologically confirmed metastatic RCC that is predominantly clear cell Measurable
   disease, as defined by RECIST

   - Age ≥ 18 years

   - ECOG performance status of 0 or 1

   - No more than 1 prior targeted therapy (eg, sorafenib, sunitinib) (prior cytokine
   therapy allowed)

   - No more than 2 prior systemic therapies

   - Ability and capacity to comply with the study and follow-up procedures

General Exclusion Criteria

   - Inability to comply with study and/or follow-up procedures

   - Life expectancy of < 12 weeks

   - Inadequate organ function, as evidenced by any of the following at screening:

      - Absolute neutrophil count (ANC) < 1500/uL

      - Platelet count ≤ 100 x 10^9/L

      - Total bilirubin ≥ 1.5 x upper limit of normal (ULN)

      - AST and/or ALT > 2.5 x ULN for patients without evidence of liver metastases, or
      5 x ULN for patients with documented liver metastases

      - Serum creatinine > 2.0 mg/dL

      - Hemoglobin < 9 g/dL (may be transfused or receive epoetin alfa to maintain or
      exceed this level)

   - Active infection or fever > 38.5°C within 3 days of starting treatment

   - Women who are pregnant or breast feeding,

   - Able to conceive and unwilling to practice an effective method of birth control.

   - History of other malignancies within 5 years prior to Day 1 except for tumors with a
   negligible risk for metastasis or death, such as adequately controlled basal cell
   carcinoma, squamous-cell carcinoma of the skin, carcinoma in situ of the cervix,
   early-stage bladder cancer, or low-grade endometrial cancer

   - Malignancies that have undergone a putative surgical cure (i.e., localized prostate
   cancer post-prostatectomy) within 5 years prior to Day 1 may be discussed with the
   Principal Investigator.

   - Any other medical conditions (including mental illness or substance abuse) deemed by
   the clinician to be likely to interfere with a patient's ability to provide informed
   consent, cooperate, or participate in the study, or to interfere with the
   interpretation of the results.

   - Current, recent (within 4 weeks of the first infusion of this study), or planned
   participation in an experimental drug study

Disease-Specific Exclusion Criteria

   - RCC with predominantly sarcomatoid features

   - Radiotherapy for RCC within 28 days prior to Day 1, with the exception of
   single-fraction radiotherapy given for the indication of pain control

   - Prior treatment with bevacizumab or any mTOR inhibitor (eg, temsirolimus, sirolimus,
   or everolimus)

   - Current need for dialysis

Bevacizumab-Specific Exclusions

   - Inadequately controlled hypertension (defined as systolic blood pressure >150 and/or
   diastolic blood pressure > 100 mmHg on antihypertensive medications)

   - Any prior history of hypertensive crisis or hypertensive encephalopathy

   - New York Heart Association (NYHA) Grade II or greater congestive heart failure

   - History of myocardial infarction or unstable angina within 6 months prior to study

   - History of stroke or transient ischemic attack within 6 months prior to study

   - Known CNS disease, except for treated brain metastasis. Treated brain metastases are
   defined as having no evidence of progression or hemorrhage after treatment and no
   ongoing requirement for dexamethasone, as ascertained by clinical examination and
   brain imaging (MRI or CT) during the screening period. Anticonvulsants (stable dose)
   are allowed. Treatment for brain metastases may include whole brain radiotherapy
   (WBRT), radiosurgery (RS; Gamma Knife, LINAC, or equivalent) or a combination as
   deemed appropriate by the treating physician. Patients with CNS metastases treated by
   neurosurgical resection or brain biopsy performed within 3 months prior to Day 1 will
   be excluded.

   - Significant vascular disease (eg, aortic aneurysm, aortic dissection)

   - Symptomatic peripheral vascular disease

   - Evidence of bleeding diathesis or coagulopathy that is not intentionally

   - Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
   prior to study enrollment or anticipation of need for major surgical procedure during
   the course of the study

   - Core biopsy or other minor surgical procedure, excluding placement of a vascular
   access device, within 7 days prior to study enrollment

   - History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess
   within 6 months prior to study enrollment

   - Serious, non-healing wound, ulcer, or bone fracture

   - Proteinuria at screening as demonstrated by a urine protein:

   - Creatinine (UPC) ratio ≥ 1.0. If UPC ratio ≥ 1.0, the patient must undergo a 24 hour
   urine collection which must demonstrate ≤ 1g of protein in 24 hours to be eligible.

   - Known hypersensitivity to any component of bevacizumab

RAD001-Specific Exclusion Criteria

   - Known hypersensitivity to any component of RAD001

   - Chronic treatment with systemic steroids or another immunosuppressive agent

   - Impairment of gastrointestinal function or gastrointestinal disease that may
   significantly alter the absorption of RAD001 (eg, ulcerative disease, uncontrolled
   nausea, vomiting, diarrhea, malabsorption syndrome or small bowel resection)

   - Severely impaired lung function (spirometry and DLCO < 50% of normal and O2 saturation
   88% or less at rest on room air)

   - If O2 saturation is ≤ 88% at rest on screening, pulmonary function tests (PFTs) will
   be ordered to confirm normal pulmonary function and eligibility.

   - Fasting total cholesterol > 350 mg/dL

   - Fasting triglyceride level > 400 mg/dL or >2.5 x ULN

   - Fasting serum glucose > 250 mg/dL

   - Serum phosphorus < 2.0 mg/dL

   - Serum corrected calcium < 8.0 mg/dL


drug: bevacizumab

drug: Everolimus

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305

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