Triclosan, Triclocarban, and the Microbiota

Not Recruiting

Trial ID: NCT01509976


Triclosan (5-chloro-2 (22,4-dichlorophenoxy)phenol) is a broad-spectrum antibacterial and antifungal agent that is found in thousands of common household products, including deodorants, toothpaste, "antibacterial" soaps, cleaning products, kitchen utensils, bedding, socks, trash bags. The benefits of triclosan have not been proven except in reducing plaque and gingivitis when used in toothpaste. In this study, the investigators intend to look at whether exposure to triclosan changes the colonizing flora of the skin, gut and mouth as well as changes in certain blood hormone levels, including adipocytokines, androgens, and inflammatory markers. Changes in the gut microbiota have been associated with a variety of disease states such as inflammatory bowel disease, colorectal cancer. Additionally, reductions in the microbiome diversity have been associated with obesity.

Official Title

Triclosan, Triclocarban, and the Microbiota

Stanford Investigator(s)

Julie Parsonnet
Julie Parsonnet

George DeForest Barnett Professor of Medicine and Professor of Epidemiology and Population Health


Inclusion Criteria:

   - Health subjects

   - Age >18 years

Exclusion Criteria:

   - Pregnancy

   - Recent travel to the developing world (within 3 months)

   - Recent use of antibiotics (within 3 months)

   - Unwillingness to change personal care/hygiene products

   - Recent gastrointestinal illness (within 3 months)

   - Individuals who are unlikely to be available for the 10 months of the study period.


other: triclosan/triclocarban-containing personal care products

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Gina A Suh, MD