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Tofacitinib for the Treatment of Alopecia Areata and Its Variants
Not Recruiting
Trial ID: NCT02312882
Purpose
The purpose of this study is to investigate the ability of tofacitinib citrate, a Janus
kinase inhibitor, to generate hair regrowth in patients with moderate to severe alopecia
areata and its variants.
Official Title
Tofacitinib for the Treatment of Alopecia Areata and Its Variants
Stanford Investigator(s)
Justin M Ko, MD, MBA
Clinical Professor, Dermatology
Anthony Oro, MD, PhD
Eugene and Gloria Bauer Professor
Eligibility
Inclusion Criteria:
- Age >= 18 years old
- Diagnosis of alopecia areata with >50% scalp involvement, alopecia totalis, or
alopecia universalis
- Hair loss present for at least 6 months
- No treatment for alopecia areata in past 2 months
- No evidence of hair regrowth
- Females of childbearing potential must use birth control while taking the medication
and there must be a negative pregnancy test documented prior to starting the
medication
- Fluent in spoken and written English
Exclusion Criteria:
- Age <18 years old
- Patients have received treatment known to affect alopecia areata within 2 months of
enrolling in the study
- Patients with a history of malignancy (except history of successfully treated basal
cell or squamous cell carcinoma of the skin)
- Patients known to be HIV or hepatitis B or C positive
- Patients with positive tuberculin skin test or positive QuantiFERON TB test
- Patients with leukopenia or anemia
- Patients with renal or hepatic impairment
- Patients with peptic ulcer disease
- Patients taking immunosuppressive medications, including but not limited to
prednisone, methotrexate, mycophenolate mofetil, azathioprine, tacrolimus,
cyclosporine, or TNH-alpha inhibitors
- Women of childbearing potential who are unable or unwilling to use birth control while
taking the medication
- Women who are pregnant or nursing
Intervention(s):
drug: Tofacitinib
Not Recruiting
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Michelle Kim