Transversus Abdominis Plane Block in Microsurgical Breast Recon w/Abdominal Free Flap in Breast CA

Not Recruiting

Trial ID: NCT02601027


The primary objective is to determine if pre-operative transversus abdominis plane (TAP) nerve blocks by continued infusion of local anesthetic post-operatively affects post-operative narcotic usage, as compared to a placebo TAP block, after breast reconstruction surgery.

Official Title

A Phase III Study of Pre-operative Transversus Abdominis Plane Blocks Using the Nimbus Ambulatory Infusion System in Patients Undergoing Abdominal Free Flap-based Breast Reconstruction

Stanford Investigator(s)

Gordon K. Lee, M.D.
Gordon K. Lee, M.D.

Professor of Surgery (Plastic and Reconstructive Surgery)

Dung Nguyen
Dung Nguyen

Clinical Professor, Surgery - Plastic & Reconstructive Surgery


Inclusion Criteria

   - Prior diagnosis or presumed diagnosis of breast cancer or undergoing prophylactic

   - Greater than 18 years old.

   - Female.

   - Undergoing microsurgical breast reconstruction with abdominal free flap.

   - Ability to understand and the willingness to sign a written informed consent document.

Exclusion Criteria

   - True allergy to local anesthetics or opioids.

   - History of addiction to narcotics within the last 24 months

   - History of chronic pain on opioids within the last 24 months.

   - Specific mental health issues such as schizophrenia or bipolar disorder.

   - Patients who are pregnant.


drug: bupivacaine infusion

drug: acetominophen

drug: Hydromorphone

drug: Oxycodone

drug: Ondansetron

device: Nimbus Infusion Pump IV Administration

procedure: Transversus Abdominis Plane (TAP) block

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Afaaf Shakir

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