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The Effect of Anesthesia on Neurodevelopmental Outcome (NDO)
Trial ID: NCT03882788
The purpose of this study is to assess whether the type of anesthesia, narcotic-based versus inhalational anesthesia administered during cardiopulmonary bypass (CPB) surgery contributes to the wide variation in neurologic recovery and developmental outcome after surgery in infants with congenital heart disease.
Anesthesia and the Developing Brain: a Comparison of Two Anesthetic Techniques
- Neonates of at least 32 weeks of gestation, infants and children up to 2 years of age
admitted to The Children's Hospital for treatment of cyanotic or non-cyanotic heart
disease requiring surgical intervention.
- Admitting diagnosis of cyanotic or non-cyanotic heart disease
- Neonates less than 32 weeks of gestational age, and children more than 2 years of age.
- Any documented central nervous system malformations.
- Any potential subject requiring unexpected postoperative Extracorporeal membrane
oxygenation (ECMO) support
drug: Fentanyl (high dose)
drug: Fentanyl (low dose)
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