The Effect of Anesthesia on Neurodevelopmental Outcome (NDO)

Not Recruiting

Trial ID: NCT03882788


The purpose of this study is to assess whether the type of anesthesia, narcotic-based versus inhalational anesthesia administered during cardiopulmonary bypass (CPB) surgery contributes to the wide variation in neurologic recovery and developmental outcome after surgery in infants with congenital heart disease.

Official Title

Anesthesia and the Developing Brain: a Comparison of Two Anesthetic Techniques

Stanford Investigator(s)


Inclusion Criteria:

   - Neonates of at least 32 weeks of gestation, infants and children up to 2 years of age
   admitted to The Children's Hospital for treatment of cyanotic or non-cyanotic heart
   disease requiring surgical intervention.

   - Admitting diagnosis of cyanotic or non-cyanotic heart disease

Exclusion Criteria:

   - Neonates less than 32 weeks of gestational age, and children more than 2 years of age.

   - Any documented central nervous system malformations.

   - Any potential subject requiring unexpected postoperative Extracorporeal membrane
   oxygenation (ECMO) support


drug: Isoflurane

drug: Fentanyl (high dose)

drug: Fentanyl (low dose)

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305