Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD

Not Recruiting

Trial ID: NCT04532424


Investigating the efficacy of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.

Official Title

Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD

Stanford Investigator(s)

Antonio Hardan, M.D.
Antonio Hardan, M.D.

Professor of Psychiatry and Behavioral Sciences


Inclusion Criteria:

   1. Diagnosis of Autism Spectrum Disorder (ASD), Asperger's or Autism.

   2. Meet criteria for ASD on clinical assessments (ADOS-2 or CARS/BOSA if conducted
   remotely & ADI-R)

   3. Aged between 12-45 years old

   4. Have a reliable informant who can complete relevant questionnaires

   5. Must have previously not responded or not tolerated 2 treatments.

Exclusion Criteria:

   1. Any contraindications for TMS e.g. history of seizures

   2. Pregnancy

   3. Any current or past history of any physical condition which in the investigator's
   opinion might put the subject at risk or interfere with study results interpretation.

   4. Active substance use (<1 week) or intoxication verified by toxicology screen--of
   cocaine, amphetamines, benzodiazepines

   5. Showing symptoms of withdrawal from alcohol or benzodiazepines

   6. DSM-5 diagnosis of bipolar disorder or a psychotic disorder e.g. schizophrenia.

   7. Significant sensory impairments such as blindness or deafness.

   8. Any other indication the PI feels would comprise data

   9. Current severe insomnia (must sleep a minimum of 4 hours the night before stimulation)

10. IQ<50 or not testable using IQ measures and no historical IQ score available

11. Currently taking Clozapine or another medication that the PI determines increases the
   risk of TMS or may disrupt the efficacy.

12. A motor threshold that is too high to allow safe/tolerable treatment.


device: Transcranial magnetic stimulation

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Eleanor J Cole, PhD