The Effect of Micro Fragmented Adipose Tissue (MFAT) on Shoulder Osteoarthritis


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Trial ID: NCT04929951


This is a non-surgical trial comparing the clinical and functional outcomes of patients with osteoarthritis treated with Intra-articular injection of Micro Fragmented Adipose Tissue versus conventional therapy of intra-articular injection of corticosteroid.

Official Title

The Effect of Micro Fragmented Adipose Tissue (MFAT) on Shoulder Osteoarthritis

Stanford Investigator(s)

Eugene Y. Roh, MD
Eugene Y. Roh, MD

Clinical Associate Professor, Orthopaedic Surgery

Geoffrey Abrams, MD
Geoffrey Abrams, MD

Associate Professor of Orthopaedic Surgery


Inclusion Criteria:

   - Age between 25 and 75 years-old

   - Diagnosis of pre-existing osteoarthritis of the glenohumeral joint

   - Working understanding of the English language and able to fully understand the

   - Capable of providing informed consent

   - Able to complete online, in-person or phone surveys for the purposes of follow-up

   - Capable of understanding pre- and post-procedure care instructions

   - Ambulatory at baseline

   - Previous trial and failure of conservative therapy consisting of a minimum of 6 weeks
   of physical therapy and trial of anti-inflammatory medications if not contraindicated,
   with or without concomitant bracing and/or injections.

Exclusion Criteria:

   - Age < 25 or > 75 years old

   - Radiographs demonstrating either no, little osteoarthritis, severe(bone on bone)

   - Prior total or partial joint replacement surgery or surgery involving cartilage

   - Previous cortisone, PRP or Hyaluronic acid intra-articular injection within the last 3

   - Co-morbidity with the rheumatologic condition, inflammatory arthritis

   - Currently undergoing immunomodulatory therapy

   - Uncontrolled endocrine disorder

   - BMI >40 or joint space not visible by ultrasound

   - Current diagnosis of osteomyelitis, human immunodeficiency virus (HIV-1, -2) and/or
   hepatitis C (HCV), infection, and poorly controlled diabetes (HgA1C >7.0)

   - Pregnancy or planned pregnancy

   - previous stem cell injection into treatment joint

   - Patient scheduled to undergo any concomitant shoulder surgical procedures or other
   surgery which may affect outcomes.

   - Coagulopathy or anticoagulant treatment

   - Chronic pain involving multiple body parts or opioid medication management

   - Diagnosis of fibromyalgia

   - Concomitant massive(2 tendons with retraction), complete rotator cuff tendon tear


biological: Micro Fragmented Adipose Tissue

biological: Corticosteroid injection


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Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Shannon Schultz, BA