The Effect of Micro Fragmented Adipose Tissue (MFAT) on Shoulder Osteoarthritis

Inclusion Criteria:

   - Age between 25 and 75 years-old

   - Diagnosis of pre-existing osteoarthritis of the glenohumeral joint

   - Working understanding of the English language and able to fully understand the
   procedure

   - Capable of providing informed consent

   - Able to complete online, in-person or phone surveys for the purposes of follow-up

   - Capable of understanding pre- and post-procedure care instructions

   - Ambulatory at baseline

   - Previous trial and failure of conservative therapy consisting of a minimum of 6 weeks
   of physical therapy and trial of anti-inflammatory medications if not contraindicated,
   with or without concomitant bracing and/or injections.

Exclusion Criteria:

   - Age < 25 or > 75 years old

   - Radiographs demonstrating either no, little osteoarthritis, severe(bone on bone)
   osteoarthritis

   - Prior total or partial joint replacement surgery or surgery involving cartilage
   regeneration

   - Previous cortisone, PRP or Hyaluronic acid intra-articular injection within the last 3
   months

   - Co-morbidity with the rheumatologic condition, inflammatory arthritis

   - Currently undergoing immunomodulatory therapy

   - Uncontrolled endocrine disorder

   - BMI >40 or joint space not visible by ultrasound

   - Current diagnosis of osteomyelitis, human immunodeficiency virus (HIV-1, -2) and/or
   hepatitis C (HCV), infection, and poorly controlled diabetes (HgA1C >7.0)

   - Pregnancy or planned pregnancy

   - previous stem cell injection into treatment joint

   - Patient scheduled to undergo any concomitant shoulder surgical procedures or other
   surgery which may affect outcomes.

   - Coagulopathy or anticoagulant treatment

   - Chronic pain involving multiple body parts or opioid medication management

   - Diagnosis of fibromyalgia

   - Concomitant massive(2 tendons with retraction), complete rotator cuff tendon tear