Using Ferumoxytol-Enhanced MRI to Measure Inflammation in Patients With Brain Tumors or Other Conditions of the CNS

Not Recruiting

Trial ID: NCT02452216


This pilot clinical trial study will assess the inflammatory response of brain tumors or other central nervous system conditions in pediatric and adult patients using ferumoxytol-enhanced MRI. Imaging features will be correlated with the number of inflammatory cells (macrophages) at histopathology. Determining the extent of inflammation associated with pathologies in the central nervous system may be helpful for diagnostic and prognostic purposes as well as monitoring treatment response of current and future immunotherapies.

Official Title

MR Imaging of Inflammatory Responses in the Central Nervous System With Ferumoxytol-Enhanced MRI

Stanford Investigator(s)

Michael Iv
Michael Iv

Clinical Professor, Radiology


Inclusion Criteria:

   - Any patient with suspected brain tumor diagnosed by MRI

   - Patients undergoing neuro-imaging evaluation by the neurosurgical service for other
   indications (e.g. vascular malformations, traumatic brain injury, ischemic and
   hemorrhagic stroke, CNS infections, and neuro-degenerative diseases)

Exclusion Criteria:

   - Informed consent cannot be obtained either from the patient or legal representative

   - Severe coexisting or terminal systemic disease that limits life expectancy or that may
   interfere with the conduct of the study

   - Contraindication to MRI (metal implants)

   - Hemosiderosis/hemochromatosis

   - Need for sedation or anesthesia (claustrophobia) that will not otherwise be undertaken
   as part of routine clinical care (e.g. routine MRI under sedation already planned)

   - Known hypersensitivity to Feraheme (ferumoxytol) or any of its components

   - Iron overload from any cause (not just hemosiderosis or hemochromatosis), even if
   secondary to frequent blood transfusions, severe chronic hemolysis, excess dietary or
   parenteral iron, or any other etiology


drug: Ferumoxytol

other: Tissue Analysis

procedure: Magnetic Resonance Imaging

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305

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