VTX-2337 and Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Not Recruiting

Trial ID: NCT01666444


The purpose of this study is to compare the overall survival of patients treated with VTX-2337 + pegylated liposomal doxorubicin (PLD) versus those treated with PLD alone in women with recurrent or persistent, epithelial ovarian, fallopian tube or primary peritoneal cancer. VTX-2337, a small molecule agonist of Toll-like Receptor 8 (TLR8), activates multiple components of the innate immune system and is being developed as a novel therapeutic agent for use in oncology. Experimental data obtained in an animal model of ovarian cancer supports the combination of VTX-2337 with PLD. In this model, the combination of VTX-2337 and PLD resulted in a significant reduction in tumor growth compared to either agent alone and an increase in the number of T lymphocytes infiltrating the tumor. The combination of PLD and VTX-2337 has been tested in a small number of women with ovarian cancer in a Phase 1b study and appears to be generally well-tolerated.

Official Title

A Randomized, Double-Blind, Placebo-Controlled Phase II Study of VTX-2337 in Combination With Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Stanford Investigator(s)

Jonathan S. Berek, MD, MMSc
Jonathan S. Berek, MD, MMSc

Laurie Kraus Lacob Professor

Manali Patel
Manali Patel

Associate Professor of Medicine (Oncology)


Inclusion Criteria:

   1. Patients must have recurrent or persistent epithelial ovarian, fallopian tube, or
   primary peritoneal carcinoma.

   2. Patients with the following histologic cell types are eligible: serous adenocarcinoma,
   endometrioid adenocarcinoma, mucinous adenocarcinoma, undifferentiated carcinoma,
   clear cell adenocarcinoma, mixed epithelial adenocarcinoma, transitional cell
   carcinoma, malignant Brenner's tumor or adenocarcinoma not otherwise specified.

   3. Patient must have measurable disease as defined by RECIST 1.1.

   4. Patients must have received treatment with a platinum-based chemotherapeutic regimen
   for management of primary disease containing carboplatin, cisplatin or another
   organoplatinum compound. This initial treatment may have included intraperitoneal
   therapy, consolidation, non-cytotoxic agents or extended therapy administered after
   surgical or non-surgical assessment.

   Patients are allowed to receive, but are not required to receive, one additional
   cytotoxic regimen for management of recurrent or persistent disease.

   Patients are allowed to have received, but are not required to have received,
   biologic/targeted therapy (e.g., bevacizumab and/or PARP inhibitor) as part of their
   primary treatment regimen or for management of recurrent or persistent disease.

   5. Patients must have platinum-resistant disease, defined as having a platinum-free
   interval (PFI) of < 12 months after first- or second-line platinum-based chemotherapy,
   or having disease progression while receiving second-line platinum-based chemotherapy.

   6. Patients must have adequate bone marrow, renal, hepatic, and neurologic functions as
   defined by the following:

      - Bone marrow function: absolute neutrophil count (ANC) ≥ 1,500/mm3. This ANC
      cannot have been induced or supported by granulocyte colony stimulating factors.
      Platelets ≥ 100,000/mm3. Hemoglobin ≥ 9 g/dL.

      - Renal function: creatinine ≤ 1.5 x institutional upper limit normal (ULN).

      - Hepatic function: bilirubin < 1.2 mg/dL, SGOT (AST) and SGPT (ALT) ≤ 3.0 x ULN
      and alkaline phosphatase ≤ 2.5 x ULN.

   7. Patients must have recovered from effects of recent surgery, radiotherapy or

      - Patients should be free of active infection requiring parenteral antibiotics.

      - Any hormonal therapy directed at the malignant tumor must be discontinued at
      least one week prior to registration. Continuation of hormone replacement therapy
      is permitted.

      - Any other prior therapy directed at the malignant tumor, including chemotherapy,
      biologic/targeted agents and immunologic agents, must be discontinued at least
      three weeks prior to registration.

      - Any prior radiation therapy must be completed at least four weeks prior to

   8. Patients must have a GOG performance status of 0 or 1.

   9. Patients of childbearing potential must have a negative pregnancy test prior to the
   study entry and be practicing an effective form of contraception. If applicable,
   patients must discontinue breastfeeding prior to study entry.

10. Patients must meet the entry requirements and undergo the baseline procedures.

11. Patients must have signed an IRB-approved informed consent form and authorization
   permitting release of personal health information.

Exclusion Criteria:

   1. Patients who have had treatment with VTX-2337, doxorubicin, PLD, or any other

   2. Patients who have received an investigational agent < 30 days prior to registration.

   3. Patients who have received oral or parenteral corticosteroids < 2 weeks prior to
   registration or who require ongoing systemic immunosuppressive therapy for any reason.

   4. Patients with active autoimmune disease. "Active" refers to any condition currently
   requiring therapy. Examples of autoimmune disease include systemic lupus
   erythematosus, multiple sclerosis, inflammatory bowel disease and rheumatoid

   5. Patients with a history of other invasive malignancies, with the exception of
   non-melanoma skin cancer, are excluded if there is any evidence of the other
   malignancy being present within the last three years.

   6. Patients who have received prior radiotherapy OTHER THAN for the treatment of ovarian,
   fallopian tube or primary peritoneal cancer within the last three years are excluded.

   7. Patients who have received prior chemotherapy OTHER THAN for the treatment of ovarian,
   fallopian tube or primary peritoneal cancer within the last three years are excluded.

   8. Patients with history or evidence upon physical examination of CNS disease, including
   primary brain tumor, seizures not controlled with standard medical therapy, any brain
   metastases, or history of cerebrovascular accident (CVA, stroke), transient ischemic
   attack (TIA) or subarachnoid hemorrhage within six months of the first date of
   treatment on this study.

   9. Patients with clinically significant cardiovascular disease.

10. Patients who are pregnant or nursing.

11. Patients under the age of 18.

12. Patients with clinical symptoms or signs of gastrointestinal obstruction and/or who
   require parenteral hydration or nutrition.


drug: pegylated liposomal doxorubicin (PLD)

drug: VTX-2337

drug: Placebo

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305

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