Vision-based Speed of Processing Cognitive Training and Mild Cognitive Impairment

Not Recruiting

Trial ID: NCT02559063


This project seeks to identify neural changes that occur in adults with mild cognitive impairment (MCI) after engagement in computerized cognitive training. In addition, this project aims to identify physiological factors that may bolster effects of the training on cognitive function. Individuals with MCI are at high risk for Alzheimer's disease (AD). Understanding how cognitive training protects cognitive function in MCI can contribute to development of effective interventions to slow progression to AD in individuals at risk, thereby reducing the significant morbidity and health care costs associated with AD.

Official Title

Neurophysiological Aspects of Vision-based Speed of Processing Cognitive Training in Older Adults With Mild Cognitive Impairment

Stanford Investigator(s)

Dana Lin, MD
Dana Lin, MD

Clinical Associate Professor, Surgery - General Surgery


Inclusion Criteria:

   - a clinical diagnosis of "mild cognitive impairment due to Alzheimer's disease" using
   the most recent NIA and Alzheimer's Association workshop criteria within 3 months: a)
   must have memory deficit (1-1.5SD below age- and education-corrected population
   norms); b) may have deficits in other cognitive domains (e.g., executive function); c)
   preserved BADL, defined as requiring occasional assistance on less than two items on
   the Minimum Data Set-Home Care interview, d) absence of dementia using NINCDS-ADRDA

   - if on AD medication (i.e., memantine or cholinesterase inhibitors), no changes of
   doses in the 3 months prior to recruitment;

   - capacity to give consent based on clinician assessment; and

   - other: age ≥60 years, English-speaking, adequate visual acuity for testing, and

Exclusion Criteria:

   - current enrollment in another cognitive improvement study;

   - major depression: 15-item Geriatric Depression Scale scored > 7;

   - MRI contraindications, e.g., metallic implant, pacemaker, claustrophobia; and

   - major vascular diseases: stroke, myocardial infarction, congestive heart failure.


behavioral: Vision-based speed of processing training

behavioral: Mental leisure activities

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305