Trial Search Results

Ibrutinib in Treating Patients With Refractory or Relapsed Lymphoma After Donor Stem Cell Transplant

This phase II trial studies how well ibrutinib works in treating patients after a donor stem cell transplant for lymphoma that is not responding to treatment or has come back. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Stanford is currently not accepting patients for this trial.

Lead Sponsor:

Vanderbilt-Ingram Cancer Center

Collaborator: National Cancer Institute (NCI)

Intervention(s):

  • Drug: Ibrutinib
  • Other: Laboratory Biomarker Analysis

Phase:

Phase 2

Eligibility


Inclusion Criteria:

PRE-STEM CELL TRANSPLANT (SCT)

   - Patients undergoing their first T cell replete allo-HCT for chronic lymphocytic
   leukemia (CLL), Hodgkin Lymphoma (HL), or the following subtypes of Non-Hodgkin
   lymphoma: Mantle cell lymphoma (MCL) and follicular center cell lymphoma (FL)

   - Meeting institutional criteria for allo-HCT. Ejection fraction by echocardiogram or
   MUGA >40%, pulmonary function test with adjusted DLCO ≥ 60%

   - Matched (8/8) or mismatched (7/8) related, unrelated HCT

   - Stem cell source: bone marrow, peripheral blood stem cell

   - Disease criteria:

Cohort A

Chronic lymphocytic leukemia

   - Disease burden: lymph node size < 5 cm and/or extra-nodal involvement < 5 cm AND

   - 17 p deletion (detected by any assay) (> or equal to 20% of cells involved if assay is
   conventional cytogenetics or fluorescence in situ hybridization [FISH]) or NOTCH
   mutation at any time point during disease course; patient should have received at
   least 1 line of therapy; prior ibrutinib therapy is permitted OR

   - Relapsed/refractory chronic lymphocytic leukemia > or equal to 2 lines of therapy;
   prior ibrutinib therapy is permitted

Mantle cell lymphoma

   - Disease burden: lymph node size < 5 cm and/or extra-nodal involvement < 5 cm AND

   - Relapsed/refractory mantle cell lymphoma > or equal to 1 line of therapy. Prior
   ibrutinib therapy is permitted. Prior autologous hematopoietic cell transplant is
   permitted. OR

   - Mantle cell lymphoma blastoid variant in first complete response (CR1) or high risk
   mantle cell lymphoma being considered for allo hematopoietic cell transplant in CR1

Cohort B

Follicular lymphoma

Disease burden: lymph node size < 5 cm and/or extra-nodal involvement < 5 cm AND
Relapsed/refractory follicular lymphoma > or equal to 2 lines of therapy. Prior ibrutinib
therapy is permitted

Hodgkin disease

   - Disease burden: lymph node size < 5 cm and/or extra-nodal involvement < 5 cm AND

   - Relapsed/refractory Hodgkin disease > or equal to 2 lines of therapy.

      - Preparative regimen: both reduced intensity and ablative regimens are permitted.
      Each center will pre-specify the regimen they intend to use during the conduct of
      the study

      - Donor criteria: HLA ≥ 7/8 related or unrelated donors.

      - Women of childbearing potential and men who are sexually active must be
      practicing a highly effective method of birth control during and after the study
      consistent with local regulations regarding the use of birth control methods for
      subjects participating in clinical trials. Men must agree to not donate sperm
      during and after the study. For females, these restrictions apply for 1 month
      after the last dose of study drug. For males, these restrictions apply for 3
      months after the last dose of study drug.

      - Women of childbearing potential must have a negative serum (beta-human chorionic
      gonadotropin [beta-hCG]) or urine pregnancy test at screening. Women who are
      pregnant or breastfeeding are ineligible for this study

      - Sign (or their legally-acceptable representatives must sign) an informed consent
      document indicating that they understand the purpose of and procedures required
      for the study, including biomarkers, and are willing to participate in the study

      - Prior to Administration of Ibrutinib (Day 60 to Day 90 post hematopoietic cell
      transplant)

   - Karnofsky performance status (KPS) > or equal to 60%

   - Engraftment of neutrophils (absolute neutrophil count [ANC] >= 1.0 X 10^9/L) for 3
   days without granulocyte colony-stimulating factor (g-csf) support

   - Platelets > or equal to 100,000/mm^3 or > or equal to = 50,000/mm^3 if bone marrow
   involvement independent of transfusion support in either situation

   - Glomerular filtration rate (GFR) > or equal to 30 ml/min

   - Liver function tests (LFTs) (alanine aminotransferase [ALT] and aspartate
   aminotransferase [AST]) equal to or < 3 X upper limit of normal (ULN)

   - Total bilirubin equal to or < 1.5 mg/dL X ULN unless bilirubin rise is due to
   Gilbert's syndrome or of non-hepatic origin

   - Predominant donor chimerisms of > or equal to 51% as measured by CD3 and CD33 (or
   other myeloid marker)

Exclusion Criteria:

PRE-SCT

   - Progression of chronic lymphocytic leukemia or mantle cell lymphoma or follicular
   lymphoma or HD at time of transplant

   - Use of Coumadin (warfarin) or other vitamin-K antagonists for anticoagulation;
   non-Coumadin anticoagulation is permitted

   - Known central nervous system involvement

   - Active uncontrolled bacterial or invasive fungal infections

   - History of malignancy other than the underlying disease unless treated with a curative
   intent and/or no evidence of disease for at least 3 years (y) OR expected to be cured
   with SCT

   - Planned use of post-hematopoietic cell transplant cyclophosphamide for graft versus
   host disease prophylaxis

   - Anticipated planned donor lymphocyte infusion in the first 3 months post-SCT

   - T deplete hematopoietic cell transplant

   - Umbilical cord hematopoietic cell transplant

   - History of stroke or intracranial hemorrhage within 6 months of enrollment

   - Clinically significant cardiovascular disease such as uncontrolled or symptomatic
   arrhythmias, congestive heart failure, or myocardial infarction within 6 months of
   screening, or any class 3 (moderate) or class 4 (severe) cardiac disease as defined by
   the New York Heart Association Functional Classification

   - Known HIV

   - Active Hepatitis B or C virus

   - Child-Pugh Class C

PRIOR TO ADMINISTRATION OF IBRUTINIB (DAY 60-DAY 90 POST SCT)

   - In the critical care unit, or use of mechanical ventilation or use of renal
   replacement therapy at any time post hematopoietic cell transplant and prior to
   administration of ibrutinib

   - Active uncontrolled stage 3-4 acute gastrointestinal (GI) graft versus host disease
   prior to administration of ibrutinib

   - Active uncontrolled stage 4 acute liver graft versus host disease prior to
   administration of ibrutinib

   - Evidence of progressive disease as compared to pre-hematopoietic cell transplant
   (persistence of disease is permitted)

   - Anticipated planned donor lymphocyte infusion in the first 3 months post-SCT

   - Active uncontrolled bacterial or invasive fungal infections

   - Prednisone equivalent of > 2m/kg for treatment of graft versus host disease prior to
   administration of ibrutinib

   - Use of second line systemic therapy for treatment of acute graft versus host disease
   prior to administration of ibrutinib

   - Any life-threatening illness, medical condition, or organ system dysfunction which, in
   the investigator's opinion, could compromise the subject's safety, interfere with the
   absorption or metabolism of ibrutinib capsules, or put the study outcomes at undue
   risk. Including the presence of chronic/active HBV and HBC infections and Child-Pugh
   Class C.ibrutinib.

   - Major surgery or a wound that has not fully healed within 4 weeks of starting.

   - Requires anticoagulation with warfarin or equivalent vitamin K antagonists (e.g.,
   phenprocoumon)

   - Requires chronic treatment with strong cytochrome P450, family 3, subfamily A (CYP3A)
   inhibitors

   - Vaccinated with live, attenuated vaccines within 4 weeks of starting ibrutinib

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Kelly Chyan
650-625-8130
Recruiting