ExAblate (MRgFUS) Treatment of Metastatic Bone Tumors for the Palliation of Pain

Not Recruiting

Trial ID: NCT00656305


A Pivotal Study to Evaluate the Effectiveness and Safety of ExAblate Treatment of Metastatic Bone and Multiple Myeloma Tumors for the Palliation of Pain in Patients Who are not Candidates for Radiation Therapy

Official Title

A Pivotal Study to Evaluate the Effectiveness and Safety of ExAblate Treatment of Metastatic and Multiple Myeloma Bone Tumors for the Palliation of Pain in Patients Who Are Not Candidates for Radiation Therapy

Stanford Investigator(s)

Pejman Ghanouni, MD, PhD
Pejman Ghanouni, MD, PhD

Associate Professor of Radiology (General Radiology) and, by courtesy, of Neurosurgery, of Obstetrics and Gynecology and of Urology

Heather Wakelee
Heather Wakelee

Winston Chen and Phyllis Huang Professor

Gloria Hwang, MD
Gloria Hwang, MD

Clinical Professor, Radiology

David Hovsepian, MD
David Hovsepian, MD

Clinical Professor, Radiology

John D. Louie, MD
John D. Louie, MD

Clinical Professor, Radiology

Daniel Sze, MD, PhD
Daniel Sze, MD, PhD

Professor of Radiology (Interventional Radiology)


Professor of Radiology (Interventional Radiology)

Nishita Kothary, MD
Nishita Kothary, MD

Professor of Radiology (Interventional Radiology)


Inclusion criteria:

   1. Men and women age 18 and older

   2. Patients who are able and willing to give consent and able to attend all study visits

   3. Patients who are suffering from symptoms of bone metastases or multiple myeloma bone
   lesions and are radiation failure patients:

   Radiation failure candidates are those who have received radiation without adequate
   relief from metastatic bone pain as determined by the patient and treating physician,
   those for whom their treating physician would not prescribe radiation or additional
   radiation treatments, and those patients who refuse additional radiation therapy,

   4. Patients who refuse other accepted available treatments such as surgery or narcotics
   for pain alleviation.

   5. Patient with NRS (0-10 scale) pain score ≥ 4 irrespective of medication

   6. Targeted tumor(s) are ExAblate device accessible and are located in ribs, extremities
   (excluding joints), pelvis, shoulders and in the posterior aspects of the following
   spinal vertebra: Lumbar vertebra (L3 - L5), Sacral vertebra (S1 - S5)

   7. Targeted tumor (treated) size up to 55 cm2 in surface area

   8. Patient whose targeted (treated) lesion is on bone and the interface between the bone
   and lesion is deeper than 10-mm from the skin.

   9. Targeted (treated) tumor clearly visible by non-contrast MRI, and ExAblate MRgFUS
   device accessible

10. Able to communicate sensations during the ExAblate treatment

11. Patients on ongoing chemotherapy regimen for at least 1 month at the time of

   - with same chemotherapy regimen (as documented from patient medical dossier),


   - Worst pain NRS still >= 4


   - do NOT plan to initiate a new chemotherapy for pain palliation should be eligible
   for the study.

12. No radiation therapy to targeted (most painful) lesion in the past two weeks

13. Bisphosphonate intake should remain stable throughout the study duration.

14. Patients will have from 1 to 5 painful lesions and only the most painful lesion will
   be treated.

15. Patients with persistent distinguishable pain associated with 1 site to be treated (if
   patient has pain from additional sites, the pain from the additional sites must be
   evaluated as being less intense by at least 2 points on the NRS compared to the site
   to be treated).

Exclusion Criteria:

   1. Patients who either

      - Need surgical stabilization of the affected bony structure (>7 fracture risk
      score, see Section 7.3) OR

      - Targeted tumor is at an impending fracture site (>7 on fracture risk score, see
      Section 7.3).


   - Patients with surgical stabilization of tumor site with metallic hardware

   2. More than 5 painful lesions, or more than 1 requiring immediate localized treatment

   3. Targeted (treated) tumor is in the skull

   4. Patients on dialysis

   5. Patients with life expectancy < 3-Months

   6. patients with an acute medical condition (e.g., pneumonia, sepsis) that is expected to
   hinder them from completing this study.

   7. Patients with unstable cardiac status including:

      - Unstable angina pectoris on medication

      - Patients with documented myocardial infarction within six months of protocol

      - Congestive heart failure requiring medication (other than diuretic)

      - Patients on anti-arrhythmic drugs

   8. Severe hypertension (diastolic BP > 100 on medication)

   9. Patients with standard contraindications for MR imaging such as non-MRI compatible
   implanted metallic devices including cardiac pacemakers, size limitations (weight >250
   pounds), etc.

10. Patients with an active infection or severe hematological, neurological, or other
   uncontrolled disease.

11. Known intolerance or allergies to the MRI contrast agent (e.g. Gadolinium or
   Magnevist) including advanced kidney disease

12. KPS Score < 60 (See "Definitions" below)

13. Severe cerebrovascular disease (multiple CVA or CVA within 6 months)

14. Individuals who are not able or willing to tolerate the required prolonged stationary
   position during treatment (approximately 2 hrs.)

15. Target (treated) tumor is less then 1cm from nerve bundles, bowels or bladder.

16. Are participating or have participated in another clinical trial in the last 30 days

17. Patients initiating a new chemotherapy regime, or radiation (for the targeted most
   painful lesion) within the last 2 weeks

18. Patients unable to communicate with the investigator and staff.

19. Patients with persistent undistinguishable pain (pain source unidentifiable)

20. Targeted (treated) tumor surface area >= 55 cm2

21. Patient whose bone-lesion interface is < 10-mm from the skin

22. Targeted (treated) tumor NOT visible by non-contrast MRI,

23. Targeted (most painful) tumor Not accessible to ExAblate

24. The targeted tumor is less than 2 points more painful compared to other painful
   lesions on the site specific NRS.


device: Sham

device: ExAblate MRfFUS

Not Recruiting

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Cancer Clinical Trials Office

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